Al Zarzour Raghdaa Hamdan, Kamarulzaman Ezatul Ezleen, Saqallah Fadi G, Zakaria Fauziahanim, Asif Muhammad, Abdul Razak Khairul Niza
Discipline of Physiology & Pharmacology, School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia.
Department of Pharmacology, Faculty of Pharmacy, Arab International University, Daraa Highway, Ghabagheb Syria.
Heliyon. 2022 Sep 18;8(9):e10665. doi: 10.1016/j.heliyon.2022.e10665. eCollection 2022 Sep.
Extensive attention has been focused on herbal medicine for the treatment of different endocrine disorders. In fact, compelling scientific evidence indicates that natural compounds might act as endocrine modulators by mimicking, stimulating, or inhibiting the actions of different hormones, such as thyroid, sex, steroidal, and glucose regulating hormones. These potentials might be effectively employed for therapeutic purposes related to the endocrine system as novel complementary choices. Nevertheless, despite the remarkable therapeutic effects, inadequate targeting efficiency and low aqueous solubility of the bioactive components are still essential challenges in their clinical accreditation. On the other hand, nanotechnology has pushed the wheels of combining inorganic nanoparticles with biological structures of medicinal bioactive compounds as one of the utmost exciting fields of research. Nanoparticle conjugations create an inclusive array of applications that provide greater compliance, higher bioavailability, and lower dosage. This can safeguard the global availability of these wealthy natural sources, regardless of their biological occurrence. This review inspects future challenges of medicinal plants in various endocrine disorders for safe and alternative treatments with examples of their nanoparticle formulations.
草药医学在治疗各种内分泌失调方面受到了广泛关注。事实上，确凿的科学证据表明，天然化合物可能通过模拟、刺激或抑制不同激素（如甲状腺激素、性激素、甾体激素和血糖调节激素）的作用来充当内分泌调节剂。这些潜力可作为新型补充选择有效地用于与内分泌系统相关的治疗目的。然而，尽管具有显著的治疗效果，但生物活性成分的靶向效率不足和水溶性低仍是其临床认可的关键挑战。另一方面，纳米技术推动了将无机纳米颗粒与药用生物活性化合物的生物结构相结合，成为最令人兴奋的研究领域之一。纳米颗粒共轭产生了一系列广泛的应用，具有更高的顺应性、更高的生物利用度和更低的剂量。这可以保障这些丰富天然资源的全球可得性，而不论其生物来源如何。本综述通过药用植物纳米颗粒制剂的实例，探讨了药用植物在各种内分泌失调中用于安全替代治疗的未来挑战。
