Tsuboi K, Hirayoshi K, Takeuchi K, Sabe H, Shimada Y, Ohshio G, Tobe T, Hatanaka M
Biochem Biophys Res Commun. 1987 Jul 31;146(2):699-704. doi: 10.1016/0006-291x(87)90585-7.
We have examined the level of the c-myc transcript in 6 esophageal, 16 gastric, 19 colorectal and 1 anal cancer tissue samples; these included four lymph nodes and six hepatic metastases obtained surgically. The esophageal cancer tissues were without an increase of the c-myc transcript, some of the gastric cancer samples showed a two to three fold increase and most of the colorectal and the one anal cancer samples showed a two to ten fold increase when compared with a normal mucosal layer. Therefore, the level of the c-myc transcript in human gastrointestinal malignancies shows organ dependency. Local, lymphatic, and hepatic metastases showed little difference in the level of c-myc mRNA from that of the primary tumor.
我们检测了6份食管癌、16份胃癌、19份结直肠癌和1份肛管癌组织样本中的c-myc转录本水平；这些样本包括4份手术获取的淋巴结和6份肝转移灶。与正常黏膜层相比，食管癌组织中的c-myc转录本未增加，部分胃癌样本显示增加了2至3倍，大多数结直肠癌和1份肛管癌样本显示增加了2至10倍。因此，人类胃肠道恶性肿瘤中c-myc转录本水平呈现器官依赖性。局部、淋巴和肝转移灶的c-myc mRNA水平与原发肿瘤相比几乎没有差异。
