Fort J G, Cowchock F S, Abruzzo J L, Smith J B
Arthritis Rheum. 1987 Jul;30(7):752-60. doi: 10.1002/art.1780300705.
Recent attention has focused on the presence of anticardiolipin (ACL) antibodies and their possible role in recurrent thrombosis and abortions in patients with systemic lupus erythematosus. We analyzed ACL antibodies in 243 consecutive patients to determine their frequency in patients with different rheumatic disorders. A significantly elevated frequency was found in patients with systemic lupus erythematosus (38%), rheumatoid arthritis (33%), and psoriatic arthritis (28%). No correlation could be found between ACL antibody levels and recurrent thrombosis. In patients with rheumatoid arthritis there was a significant correlation between ACL antibodies and a history of repeated abortions. No significant association was found between ACL antibodies and other autoantibodies except in patients with rheumatoid arthritis; ACL antibody-positive rheumatoid arthritis patients were much more likely to be antinuclear antibody-positive (P less than 0.0002).
最近，注意力集中在抗心磷脂（ACL）抗体的存在及其在系统性红斑狼疮患者反复血栓形成和流产中可能发挥的作用上。我们分析了243例连续患者的ACL抗体，以确定其在不同风湿性疾病患者中的出现频率。在系统性红斑狼疮患者（38%）、类风湿关节炎患者（33%）和银屑病关节炎患者（28%）中发现频率显著升高。未发现ACL抗体水平与反复血栓形成之间存在相关性。在类风湿关节炎患者中，ACL抗体与反复流产史之间存在显著相关性。除类风湿关节炎患者外，未发现ACL抗体与其他自身抗体之间存在显著关联；ACL抗体阳性的类风湿关节炎患者更有可能抗核抗体阳性（P小于0.0002）。
