Department of Bioscience and Biotechnology, Faculty of Agriculture, University of the Ryukyus, 1 Senbaru, Nishihara, Okinawa 903-0213, Japan.
Ōmura Satoshi Memorial Institute, Kitasato University, 5-9-1 Shirokane, Minato-ku, Tokyo 108-8641, Japan.
J Asian Nat Prod Res. 2023 Jul-Aug;25(7):704-710. doi: 10.1080/10286020.2022.2130266. Epub 2022 Oct 6.
Determining the structures of new natural products from marine species not only enriches our understanding of the diverse chemistry of these species, but can also lead to the discovery of compounds with novel and/or important biological activities. Herein, we describe the isolation of isomaneonene C (), a new halogenated C acetogenin, and three known compounds, -snyderol (), -maneonene D (), and isomaneonene B (), from the organic extract obtained from the red alga cf. collected from Iheya Island, Okinawa, Japan. The structures of these secondary metabolites were elucidated spectroscopically. All compounds were inactive at 30 μg/disc against methicillin-resistant (MRSA) in combination treatment with a βlactam drug, meropenem.
从海洋物种中确定新天然产物的结构不仅丰富了我们对这些物种多样化化学性质的理解,而且还可以发现具有新颖和/或重要生物活性的化合物。在此,我们描述了从日本冲绳伊平屋岛采集的红藻 cf. 中获得的有机提取物中分离出的新型卤代 C 乙酰基内酯异曼内酮 C(),以及三种已知化合物 -snyderol()、-maneonene D()和异曼内酮 B()。这些次生代谢物的结构通过光谱法阐明。在与β-内酰胺类药物美罗培南联合治疗时,所有化合物在 30μg/disc 时对耐甲氧西林金黄色葡萄球菌(MRSA)均无活性。