一种来自红海软珊瑚的新海松烷二萜。

A new cembranoid from the Red Sea soft coral .

机构信息

Chemistry of Medicinal Plants Dept, Chemistry of Medicinal Plants, Dokki, Giza, Egypt.

Chemistry of Natural and Microbial Products Department, National Research Centre, Dokki, Giza, Egypt.

出版信息

Nat Prod Res. 2024 Jan-Feb;38(3):512-522. doi: 10.1080/14786419.2022.2130915. Epub 2022 Oct 6.

DOI:10.1080/14786419.2022.2130915

PMID:36200738

Abstract

The Red Sea soft coral ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A (), along with six known metabolites have been isolated from for the first time (). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205). Sarcacutumolid A () and gorgosterol () inhibited colorectal cancer cell proliferation in a concentration-dependent manner with IC values of 35.5 and 44.0 μM, respectively.

摘要

红海软珊瑚乙酸乙酯提取物提供了一个新的海松烷型倍半萜；sarcacutumolid A ()，同时首次从中分离出六个已知代谢产物（）。通过多种光谱分析阐明了化学结构。对分离得到的化合物进行了体外细胞毒活性评价，选用了四种人源癌细胞系：肝癌（HepG2）、宫颈癌细胞（HeLa）、乳腺癌（MCF-7）和结直肠癌细胞（Colo-205）。Sarcacutumolid A () 和 gorgosterol () 以浓度依赖性方式抑制结直肠癌细胞增殖，IC 值分别为 35.5 和 44.0 μM。