沙氏软珊瑚中聚氧倍半萜： sarcoconvolutums F 和 G

Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from , a Red Sea Soft Coral.

机构信息

Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.

Department of Natural Compounds Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.

出版信息

Molecules. 2022 Sep 8;27(18):5835. doi: 10.3390/molecules27185835.

DOI:10.3390/molecules27185835

PMID:36144570

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9500913/

Abstract

Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. (Alcyoniidae) a Red Sea-derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F () and G (), as well as four identified analogues (-) together with a furan derivate () were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F () contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites (-) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound exhibited an IC 56 µM and 55 µM against A549 and HSC-2 cells, respectively.

摘要

天然产物和化学类似物被广泛应用于药物发现，尤其是在癌症和传染病的药物治疗中。(Alcyoniidae)一种源自红海的软珊瑚已被证明是大环二萜和环化衍生物的丰富来源。从溶剂提取物中分离得到了两种以前未描述的多氧化的海松烷型二萜类化合物， sarcoconvolutums F()和 G()，以及四种已鉴定的类似物(-)以及一种呋喃衍生物()。通过包括 NMR、HREIMS 和 CD 在内的光谱技术以及与先前发表的数据的密切光谱比较来鉴定化合物。Sarcoconvolutum F()含有罕见的 1-过氧化物-15-羟基-10-烯官能团。分离出的代谢物(-)对肺腺癌(A549)、宫颈癌(HeLa)和口腔癌(HSC-2)细胞进行了筛选。化合物()对 A549 和 HSC-2 细胞的 IC 56 µM 和 55 µM 分别。