Steinhauer S R, Hill S Y, Zubin J
Alcohol. 1987 Jul-Aug;4(4):307-14. doi: 10.1016/0741-8329(87)90028-0.
Preliminary results are presented for auditory ERPs recorded from members of alcoholic families during performance of a counting task and a choice reaction task. Alcoholic families included three adult male siblings (alcoholic proband, a second affected sib, and an unaffected sib) and parents. Control families included two adult male sibs and parents. In all experimental conditions, the N100 component was decreased in amplitude for all sibs (affected and unaffected) of the alcoholic families. The latency of the P300 component was increased for both affected and unaffected sibs compared to controls in the counting task, indicating a familial difference irrespective of drinking status. In the choice reaction task, longer P300 latencies were observed among the probands and their affected sibs as compared to their unaffected sibs, suggesting that in this more demanding task, increased latency was associated with a significant drinking history. ERP findings for children of the alcoholic probands are also discussed. The effects of differences in task complexity, drinking variables, and criteria for family selection are considered.
本文呈现了在执行计数任务和选择反应任务期间，对酒精成瘾家族成员记录的听觉事件相关电位（ERP）的初步结果。酒精成瘾家族包括三个成年男性兄弟姐妹（酒精成瘾先证者、另一个受影响的兄弟姐妹和一个未受影响的兄弟姐妹）及其父母。对照家族包括两个成年男性兄弟姐妹及其父母。在所有实验条件下，酒精成瘾家族中所有兄弟姐妹（受影响和未受影响）的N100成分波幅均降低。在计数任务中，与对照组相比，受影响和未受影响的兄弟姐妹的P300成分潜伏期均延长，这表明无论饮酒状况如何，存在家族差异。在选择反应任务中，与未受影响的兄弟姐妹相比，先证者及其受影响的兄弟姐妹的P300潜伏期更长，这表明在这个要求更高的任务中，潜伏期延长与显著的饮酒史相关。本文还讨论了酒精成瘾先证者子女的ERP研究结果。考虑了任务复杂性、饮酒变量和家族选择标准差异的影响。
