淋病奈瑟菌感染在女性中增加，随着伴侣中淋球菌负担的增加而增加：衣原体合并感染在女性中增加淋球菌负担。

Neisseria gonorrhoeae Infection in Women Increases With Rising Gonococcal Burdens in Partners: Chlamydia Coinfection in Women Increases Gonococcal Burden.

机构信息

Sexually Transmitted Disease Clinic, Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China.

Environmental Health and Safety, Boston University, Boston, MA, USA.

出版信息

J Infect Dis. 2022 Dec 13;226(12):2192-2203. doi: 10.1093/infdis/jiac408.

DOI:10.1093/infdis/jiac408

PMID:36201640

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10205615/

Abstract

BACKGROUND

Likelihood of Neisseria gonorrhoeae infection in women exposed to male sex partners with increasing N. gonorrhoeae burdens and enhancement by Chlamydia trachomatis is not defined.

METHODS

We identified men with urethritis and their regular female sex partners. Exposure to N. gonorrhoeae burdens in men was compared in N. gonorrhoeae-infected versus -uninfected partners. Association of N. gonorrhoeae infection in women with burdens in male partners was estimated using logistic regression. Association of C. trachomatis coinfection and N. gonorrhoeae burdens in women adjusted for burdens in male partners was estimated by linear regression.

RESULTS

In total, 1816 men were enrolled; 202 had ≥2 partners, 91 who confirmed monogamy and were enrolled; 77% were married. Seventy were partners of N. gonorrhoeae-infected men; 58 (83%) were N. gonorrhoeae infected, 26 (45%) C. trachomatis coinfected. Infected women had partners with 9.3-fold higher N. gonorrhoeae burdens than partners of uninfected women (P = .0041). Association of N. gonorrhoeae infection in women with upper quartiles of N. gonorrhoeae burdens in partners increased (odds ratios ≥ 2.97)compared to the first quartile (P = .032). N. gonorrhoeae burdens in C. trachomatis-coinfected women were 2.82-fold higher than in C. trachomatis-uninfected women (P = .036).

CONCLUSIONS

N. gonorrhoeae infections increased in women whose partners were infected with higher N. gonorrhoeae burdens. C. trachomatis coinfection was associated with increased N. gonorrhoeae burdens in women.

摘要

背景

男性性伴侣淋球菌负荷增加且合并沙眼衣原体感染时，女性感染淋球菌的可能性增加，但女性暴露于男性性伴侣淋球菌负荷的具体情况尚未明确。

方法

我们招募了患有尿道炎的男性及其固定性伴侣。比较了男性性伴侣中淋球菌感染者与未感染者的淋球菌暴露情况。采用逻辑回归估计女性淋球菌感染与男性性伴侣淋球菌负荷的关系。采用线性回归估计调整了男性性伴侣淋球菌负荷后，沙眼衣原体合并感染与女性淋球菌负荷的关系。

结果

共纳入 1816 名男性；202 名男性有≥2 个性伴侣，91 名男性确认其为单一性伴侣且纳入研究；77%的男性已婚。70 名男性为淋球菌感染者的性伴侣；70 名性伴侣中，58 名（83%）为淋球菌感染者，26 名（45%）为沙眼衣原体合并感染者。感染女性的性伴侣淋球菌负荷是未感染女性性伴侣的 9.3 倍（P=0.0041）。与第一四分位相比，女性性伴侣淋球菌负荷处于上四分位的女性发生淋球菌感染的比值比（OR）增加（OR≥2.97，P=0.032）。沙眼衣原体合并感染者的淋球菌负荷是沙眼衣原体未感染者的 2.82 倍（P=0.036）。