Chen Xia, Li Longquan, Liang Yuan, Huang Taobi, Zhang Huiyun, Fan Shanlin, Sun Weiming, Wang Yuping
Department of Gastroenterology; Key Laboratory for Gastrointestinal Diseases of Gansu Province, The First Hospital of Lanzhou University, Lanzhou, China.
Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, China.
J Cancer Res Ther. 2022 Sep;18(5):1417-1424. doi: 10.4103/jcrt.jcrt_527_21.
The purpose of this meta-analysis was to investigate whether vitamin D intake, serum 25(OH) D, and solar ultraviolet-B (UVB) radiation have an effect on the incidence of gastric cancer. Keyword searches of online databases were performed from January 2000 to October 2020. A comprehensive analysis was conducted on the relationship of vitamin D intake, serum 25(OH) D level, and UVB radiation with the risk of gastric cancer. A total of 11 articles were included and analyzed. When the highest and lowest intake levels of vitamin D were compared, no significant association was found between vitamin D intake and gastric cancer incidence [effect size (ES): 1, 95% confidence interval (CI): 0.86-1.16, P = 0.983]. The ES of serum 25(OH) D level and gastric cancer incidence was 0.93 (95% CI: 0.77-1.11, P = 0.4), suggesting no relationship between 25(OH) D level and gastric cancer risk. High UVB radiation was associated with lower gastric cancer incidence (ES: 0.86, 95% CI: 0.84-0.89, P = 0) compared with low UVB radiation. Vitamin D intake and serum 25(OH) D level had no relationship with the risk of gastric cancer. However, an inverse association was found between solar UVB radiation and gastric cancer incidence.
本荟萃分析的目的是研究维生素D摄入量、血清25(OH)D和太阳紫外线B（UVB）辐射是否对胃癌发病率有影响。于2000年1月至2020年10月对在线数据库进行关键词检索。对维生素D摄入量、血清25(OH)D水平和UVB辐射与胃癌风险之间的关系进行了综合分析。共纳入并分析了11篇文章。比较维生素D的最高和最低摄入量水平时，未发现维生素D摄入量与胃癌发病率之间存在显著关联[效应量（ES）：1，95%置信区间（CI）：0.86 - 1.16，P = 0.983]。血清25(OH)D水平与胃癌发病率的ES为0.93（95%CI：0.77 - 1.11，P = 0.4），表明25(OH)D水平与胃癌风险之间无关联。与低UVB辐射相比，高UVB辐射与较低的胃癌发病率相关（ES：0.86，95%CI：0.84 - 0.89，P = 0）。维生素D摄入量和血清25(OH)D水平与胃癌风险无关。然而，发现太阳UVB辐射与胃癌发病率之间存在负相关。
