Medical Department of Xizang Minzu University, Xianyang, China.
Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Front Immunol. 2022 Sep 21;13:974332. doi: 10.3389/fimmu.2022.974332. eCollection 2022.
() is a globally distributed food-borne parasite that can coexist with the host for a long time after infection. -derived secretions can regulate the immune response and fibroblasts of the host, but the specific mechanisms involved are still unclear. The purpose of this study was to investigate the role of larvae-derived extracellular vesicles (EVs) and their key miRNAs in the process of -host interaction. In this study, we found that the EVs of larvae, as well as miR-1-3p and let-7-5p, expressed in larvae-derived EVs, can promote the polarization of bone marrow macrophages to M2b type while inhibiting the activation of fibroblasts. These findings will contribute to further understanding of the molecular mechanisms underlying -host interactions.
() 是一种全球性分布的食源性寄生虫，感染后可以与宿主长期共存。-衍生的分泌物可以调节宿主的免疫反应和成纤维细胞，但具体涉及的机制仍不清楚。本研究旨在探讨 幼虫衍生的细胞外囊泡（EVs）及其关键 miRNAs 在 -宿主相互作用过程中的作用。在这项研究中，我们发现 幼虫衍生的 EVs 以及在 幼虫衍生的 EVs 中表达的 miR-1-3p 和 let-7-5p 可以促进骨髓巨噬细胞向 M2b 型极化，同时抑制成纤维细胞的激活。这些发现将有助于进一步了解 -宿主相互作用的分子机制。
