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不同来源外泌体携带的核酸和蛋白质：在肝脏疾病中的潜在作用。

Nucleic acids and proteins carried by exosomes from various sources: Potential role in liver diseases.

作者信息

Xie Danna, Qian Baolin, Li Xun

机构信息

The First Clinical Medical College of Lanzhou University, Lanzhou, China.

Department of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, China.

出版信息

Front Physiol. 2022 Sep 23;13:957036. doi: 10.3389/fphys.2022.957036. eCollection 2022.

DOI:10.3389/fphys.2022.957036
PMID:36213232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9538374/
Abstract

Exosomes are extracellular membrane-encapsulated vesicles that are released into the extracellular space or biological fluids by many cell types through exocytosis. As a newly identified form of intercellular signal communication, exosomes mediate various pathological and physiological processes by exchanging various active substances between cells. The incidence and mortality of liver diseases is increasing worldwide. Therefore, we reviewed recent studies evaluating the role of exosomes from various sources in the diagnosis and treatment of liver diseases.

摘要

外泌体是细胞外膜包裹的囊泡，由多种细胞类型通过胞吐作用释放到细胞外空间或生物体液中。作为一种新发现的细胞间信号通讯形式，外泌体通过在细胞间交换各种活性物质来介导各种病理和生理过程。在全球范围内，肝脏疾病的发病率和死亡率都在上升。因此，我们综述了近期评估各种来源外泌体在肝脏疾病诊断和治疗中作用的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/0e16027a04b8/fphys-13-957036-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/f739a26edbe8/fphys-13-957036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/18bf532aff68/fphys-13-957036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/6c719051a90a/fphys-13-957036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/57cb1c77d478/fphys-13-957036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/752832eb3de4/fphys-13-957036-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/0e16027a04b8/fphys-13-957036-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/f739a26edbe8/fphys-13-957036-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/18bf532aff68/fphys-13-957036-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/6c719051a90a/fphys-13-957036-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/57cb1c77d478/fphys-13-957036-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/752832eb3de4/fphys-13-957036-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/174a/9538374/0e16027a04b8/fphys-13-957036-g006.jpg

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本文引用的文献

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MicroRNAs: Novel Targets in Hepatic Ischemia-Reperfusion Injury.微小RNA：肝脏缺血再灌注损伤中的新靶点
Biomedicines. 2022 Mar 29;10(4):791. doi: 10.3390/biomedicines10040791.
2
Exosomal Carboxypeptidase E (CPE) and CPE-shRNA-Loaded Exosomes Regulate Metastatic Phenotype of Tumor Cells.外泌体羧肽酶 E（CPE）和 CPE-shRNA 负载的外泌体调节肿瘤细胞的转移表型。
Int J Mol Sci. 2022 Mar 14;23(6):3113. doi: 10.3390/ijms23063113.
3
Role of Mitochondrial Pathways in Cell Apoptosis during He-Patic Ischemia/Reperfusion Injury.线粒体途径在肝缺血/再灌注损伤细胞凋亡中的作用。
Int J Mol Sci. 2022 Feb 21;23(4):2357. doi: 10.3390/ijms23042357.
4
Exosome as a target for cancer treatment.外泌体作为癌症治疗的靶点。
J Investig Med. 2022 Jun;70(5):1212-1218. doi: 10.1136/jim-2021-002194. Epub 2022 Feb 24.
5
Exosome-mediated delivery of RBP-J decoy oligodeoxynucleotides ameliorates hepatic fibrosis in mice.外泌体介导的 RBP-J 诱饵寡脱氧核苷酸递送至小鼠肝脏改善肝纤维化。
Theranostics. 2022 Jan 24;12(4):1816-1828. doi: 10.7150/thno.69885. eCollection 2022.
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Hepatocellular carcinoma serum derived exosomal HIF-1α induces phosphoinositide-3 kinase/protein kinase B signaling to induce the angiogenesis and proliferation of HCC.肝癌血清来源的外泌体缺氧诱导因子-1α诱导磷脂酰肌醇-3激酶/蛋白激酶B信号传导，从而诱导肝癌的血管生成和增殖。
Transl Cancer Res. 2019 Aug;8(4):1550-1559. doi: 10.21037/tcr.2019.08.07.
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Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis.间质干细胞来源的外泌体 circDIDO1 通过 miR-141-3p/PTEN/AKT 通路抑制人肝纤维化中肝星状细胞的激活。
Drug Deliv. 2022 Dec;29(1):440-453. doi: 10.1080/10717544.2022.2030428.
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Exosomes derived from hepatitis B virus-infected hepatocytes promote liver fibrosis via miR-222/TFRC axis.乙型肝炎病毒感染的肝细胞来源的外泌体通过 miR-222/TFRC 轴促进肝纤维化。
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