营养素摄入与共病对绝经前和绝经后妇女生活质量的交互作用。

Interactions between nutrient intake and comorbidities for quality of life in premenopausal and postmenopausal women.

机构信息

From the Department of Pharmacy, College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University, Sunchon, Jeonnam, Republic of Korea.

出版信息

Menopause. 2022 Nov 1;29(11):1285-1295. doi: 10.1097/GME.0000000000002064. Epub 2022 Oct 10.

DOI:10.1097/GME.0000000000002064

PMID:36219811

Abstract

OBJECTIVE

This study aimed to identify the associations between nutrient intake and health-related quality of life (HRQOL) in premenopausal and postmenopausal women.

METHODS

Using data from Korean National Health and Nutrition Examination Surveys (2019-2020), EQ-5D-3L, and multivariate logistic and linear regression models, we analyzed the association and interaction between nutrient intake, comorbidities, and HRQOL among 4,027 Korean women.

RESULTS

Nutrient intake levels were lower in postmenopausal women than in premenopausal women. Interactions were observed between numerous nutrient intakes and comorbidities for HRQOL among premenopausal and postmenopausal women. Higher intakes of various nutrients (particularly, folic acid and vitamin A) were related to higher HRQOL scores in premenopausal women with comorbidities (log of inverse HRQOL scores, β = -0.31 [95% confidence interval [CI], -0.58 to -0.05] and β = -0.19 [95% CI, -0.37 to -0.001]) and postmenopausal women with comorbidities (log of inverse HRQOL scores, β = -0.34 [95% CI, -0.61 to -0.07] and β = -0.19 [95% CI, -0.38 to -0.01]), respectively. Regular exercise was associated with a lower risk of mobility problems (odds ratio [OR], 0.59; 95% CI, 0.44-0.81), self-care problems (OR, 0.53; 95% CI, 0.28-0.99), usual activity problems (OR, 0.42; 95% CI, 0.26-0.67), and any problem (OR, 0.71; 95% CI, 0.56-0.90), as well as an increase in HRQOL score (log of inverse HRQOL scores, β = -0.42; 95% CI, -0.68 to -0.16) in postmenopausal women. Smoking was related to a higher prevalence of depression and anxiety problems (OR, 2.51; 95% CI, 1.53-4.13) and any problem (OR, 1.67; 95% CI, 1.11-2.52), as well as a decrease in HRQOL scores (log of inverse HRQOL scores, β = 0.51; 95% CI, 0.14-0.88) in premenopausal women.

CONCLUSIONS

Given the lower nutrient intake levels in postmenopausal women, it is critical to establish HRQOL-improving approaches for this population, including regular exercise, nutrient intake, and smoking cessation.

摘要

目的

本研究旨在确定绝经前和绝经后妇女的营养摄入与健康相关生活质量（HRQOL）之间的关联。

方法

使用 2019-2020 年韩国国家健康和营养检查调查（KNHANES）的数据、EQ-5D-3L 量表以及多变量逻辑回归和线性回归模型，我们分析了 4027 名韩国女性中营养摄入、合并症与 HRQOL 之间的关联和相互作用。

结果

绝经后妇女的营养摄入水平低于绝经前妇女。绝经前和绝经后妇女中，多种营养素摄入与合并症之间存在交互作用。较高的各种营养素摄入（特别是叶酸和维生素 A）与患有合并症的绝经前妇女（逆 HRQOL 评分的对数，β=−0.31[95%置信区间（CI），−0.58 至−0.05]和β=−0.19[95%CI，−0.37 至−0.001]）和患有合并症的绝经后妇女（逆 HRQOL 评分的对数，β=−0.34[95%CI，−0.61 至−0.07]和β=−0.19[95%CI，−0.38 至−0.01]）的 HRQOL 评分较高有关。定期运动与移动问题（优势比[OR]，0.59；95%CI，0.44-0.81）、自理问题（OR，0.53；95%CI，0.28-0.99）、日常活动问题（OR，0.42；95%CI，0.26-0.67）和任何问题（OR，0.71；95%CI，0.56-0.90）的风险降低以及绝经后妇女 HRQOL 评分（逆 HRQOL 评分的对数，β=−0.42；95%CI，−0.68 至−0.16）升高有关。吸烟与抑郁和焦虑问题（OR，2.51；95%CI，1.53-4.13）和任何问题（OR，1.67；95%CI，1.11-2.52）的发生率较高以及绝经前妇女 HRQOL 评分（逆 HRQOL 评分的对数，β=0.51；95%CI，0.14-0.88）降低有关。