Williams L R
Exp Neurol. 1987 Sep;97(3):555-63. doi: 10.1016/0014-4886(87)90113-0.
Recent investigations using synthetic entubation materials have demonstrated that nerve regeneration across a gap requires peripheral nervous tissue as a distal component within the chamber. Regeneration fails if the distal end of the regeneration chamber remains open to the environment, or is filled with tendon or skin. These results are contrary to those of Weiss and Taylor (1944) who used homologous aorta as a chamber material and found that regeneration was successful across a gap regardless of the distal tissue, even in the branches of the aorta that were closed or open. In the present report, silicone Y chambers were implanted with the distal branch remaining open, or filled with pieces of nerve, tendon, or isologous aorta. A homogenous fibrin matrix formed in all the chamber branches by 1 week postimplantation. At 4 weeks, regeneration across a 10-mm gap failed in the chamber branches that were open or filled with tendon. However, regeneration was successful in those branches containing aorta or nerve. These experiments strongly support the hypothesis that aorta tissue, like peripheral nervous tissue, is a source of regeneration-promoting materials. The results provide a probable explanation for and a reconciliation of the discrepancies between the earlier observations of Weiss and Taylor and those of more recent investigators.
近期使用合成插管材料的研究表明，神经跨越间隙的再生需要外周神经组织作为腔室内的远端成分。如果再生腔室的远端对环境开放，或者充满肌腱或皮肤，再生就会失败。这些结果与魏斯和泰勒（1944年）的研究结果相反，他们使用同种主动脉作为腔室材料，发现无论远端组织如何，即使在主动脉封闭或开放的分支中，跨越间隙的再生都是成功的。在本报告中，将硅胶Y形腔室植入，其远端分支保持开放，或填充神经、肌腱或同种主动脉碎片。植入后1周，在所有腔室分支中形成了均匀的纤维蛋白基质。4周时，在开放或填充肌腱的腔室分支中，跨越10毫米间隙的再生失败。然而，在含有主动脉或神经的分支中，再生是成功的。这些实验有力地支持了这样一种假设，即主动脉组织与外周神经组织一样，是促进再生物质的来源。这些结果为魏斯和泰勒早期观察结果与近期研究者观察结果之间的差异提供了一个可能的解释和调和。
