Center for Reproductive Medicine, Tianjin Central Hospital of Obstetrics and Gynecology, Maternal Hospital of Nankai University, Tianjin Key Laboratory of Human Development and Reproductive Regulation, Tianjin, China.
Front Immunol. 2022 Sep 27;13:973600. doi: 10.3389/fimmu.2022.973600. eCollection 2022.
Although periconception vaccination is important to maternal and neonatal health, little is known about the COVID-19 vaccine hesitancy among infertile couples seeking fertility treatment. Thus, we conducted this survey among infertile patients in a reproductive medicine center, between September 2021 and December 2021, to estimate the prevalence of COVID-19 vaccine hesitancy and its influencing factors. Information was collected through face-to-face interviews among volunteers. Among the 987 included interviewees, 17.33% reported hesitancy in primary vaccination, 25.63% reported hesitancy in booster vaccination, and 32.32% delayed the primary vaccination. Hesitancy in primary vaccination was associated with unexplained infertility (OR: 1.77, 95% CI: 1.05-2.98), ongoing IVF treatment (OR: 2.17, 95% CI: 1.22-3.89), concerns for vaccine safety (OR: 4.13, 95% CI: 2.66-6.42), effectiveness (OR: 1.62, 95% CI: 1.15-2.28), and influence on pregnancy (OR: 2.80, 95% CI: 1.68-4.67). These factors were also associated with hesitancy in booster vaccination. Delay of the primary vaccination was inversely associated with a college or above degree (OR: 0.49, 95% CI: 0.27-0.87), previous history of influenza vaccination (OR: 0.67, 95% CI: 0.46-0.98), and was positively associated with concerns for the influence on pregnancy (OR: 7.78, 95% CI: 5.01-12.07). It is necessary to carry out targeted education program by health professionals to publicize the benefits of periconception vaccination, and to reduce the resistance to COVID-19 vaccine among infertile couples.
虽然围孕期接种对于母婴健康很重要，但对于寻求生育治疗的不孕夫妇对 COVID-19 疫苗的犹豫知之甚少。因此，我们在 2021 年 9 月至 2021 年 12 月期间在一家生殖医学中心对不孕患者进行了这项调查，以估计 COVID-19 疫苗犹豫的流行率及其影响因素。通过志愿者面对面访谈收集信息。在纳入的 987 名受访者中，17.33%报告初级疫苗接种犹豫，25.63%报告加强疫苗接种犹豫，32.32%延迟了初级疫苗接种。初级疫苗接种犹豫与不明原因不孕（OR：1.77，95%CI：1.05-2.98）、正在进行的 IVF 治疗（OR：2.17，95%CI：1.22-3.89）、对疫苗安全性（OR：4.13，95%CI：2.66-6.42）、有效性（OR：1.62，95%CI：1.15-2.28）和对妊娠的影响（OR：2.80，95%CI：1.68-4.67）有关。这些因素也与加强疫苗接种犹豫有关。初级疫苗接种的延迟与大学或以上学历（OR：0.49，95%CI：0.27-0.87）、既往流感疫苗接种史（OR：0.67，95%CI：0.46-0.98）呈负相关，与对妊娠影响的担忧呈正相关（OR：7.78，95%CI：5.01-12.07）。有必要由卫生专业人员开展有针对性的教育计划，宣传围孕期接种的益处，并降低不孕夫妇对 COVID-19 疫苗的抵制。
