Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC 27101, USA.
Department of Cancer Biology, Wake Forest Baptist Medical Center, Wake Forest University, Winston-Salem, NC 27101, USA.
Semin Cancer Biol. 2022 Nov;86(Pt 3):1158-1174. doi: 10.1016/j.semcancer.2022.10.001. Epub 2022 Oct 13.
Metabolic reprogramming is an important cancer hallmark that plays a key role in cancer malignancies and therapy resistance. Cancer cells reprogram the metabolic pathways to generate not only energy and building blocks but also produce numerous key signaling metabolites to impact signaling and epigenetic/transcriptional regulation for cancer cell proliferation and survival. A deeper understanding of the mechanisms by which metabolic reprogramming is regulated in cancer may provide potential new strategies for cancer targeting. Recent studies suggest that deregulated transcription factors have been observed in various human cancers and significantly impact metabolism and signaling in cancer. In this review, we highlight the key transcription factors that are involved in metabolic control, dissect the crosstalk between signaling and transcription factors in metabolic reprogramming, and offer therapeutic strategies targeting deregulated transcription factors for cancer treatment.
代谢重编程是癌症的一个重要标志，在癌症恶性进展和治疗耐药中发挥关键作用。癌细胞重新编程代谢途径，不仅产生能量和构建块，还产生许多关键信号代谢物，影响信号转导和表观遗传/转录调控，促进癌细胞增殖和存活。深入了解代谢重编程在癌症中的调控机制，可能为癌症靶向治疗提供新的策略。最近的研究表明，在各种人类癌症中观察到失调的转录因子，这些转录因子显著影响癌症中的代谢和信号转导。在本综述中，我们重点介绍了参与代谢调控的关键转录因子，剖析了信号转导与代谢重编程中转录因子之间的相互作用，并提出了针对失调转录因子的治疗策略，以用于癌症治疗。
