Gasdermin家族蛋白在肝细胞癌发生发展中的作用。
Role of gasdermin family proteins in the occurrence and progression of hepatocellular carcinoma.
作者信息
Miao Yandong, Chen Yonggang, Mi Denghai
机构信息
The Cancer Center, Yantai Affiliated Hospital of Binzhou Medical University, The 2nd Medical College of Binzhou Medical University, Yantai 264000, Shandong Province, China.
Shenzhen Hospital of Southern Medical University, Shenzhen 518100, Guangdong Province, China.
出版信息
Heliyon. 2022 Oct 10;8(10):e11035. doi: 10.1016/j.heliyon.2022.e11035. eCollection 2022 Oct.
Primary liver cancer is the sixth most common cancer and the third leading cause of cancer mortality worldwide, hepatocellular carcinoma (HCC) is the most common type of liver cancer, accounting for 75%-85% of cases. The occurrence and progression of HCC involve multiple events. Pyroptosis is a gasdermins mediated programmed cell death and is intricately associated with cancerogenesis, including HCC. This review mainly concerns the recent research advances of the gasdermin family members in HCC. The biological roles and specific expression patterns of the family members are discussed, especially those that are involved in the regulatory pathways in the occurrence and progression of HCC. We provide the latest progress into the distinct molecular mechanisms of gasdermin family members involved in the occurrence and development of HCC.
原发性肝癌是全球第六大常见癌症，也是癌症死亡的第三大主要原因，肝细胞癌（HCC）是最常见的肝癌类型，占病例的75%-85%。HCC的发生和进展涉及多个事件。细胞焦亡是一种由gasdermins介导的程序性细胞死亡，与包括HCC在内的肿瘤发生密切相关。本综述主要关注gasdermin家族成员在HCC中的最新研究进展。讨论了该家族成员的生物学作用和特定表达模式，特别是那些参与HCC发生和进展调控途径的成员。我们提供了gasdermin家族成员参与HCC发生和发展的独特分子机制的最新进展。
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