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利用鸡肝微粒体比较氟虫腈在禽类体内的生物转化。

Comparative biotransformation of fipronil in domestic poultry using liver microsome.

机构信息

Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok 10900, Thailand.

Department of Farm Resources and Production Medicine, Faculty of Veterinary Medicine, Kasetsart University, Kamphaeng Saen Campus, Nakhon Pathom 73140, Thailand.

出版信息

J Vet Sci. 2022 Nov;23(6):e82. doi: 10.4142/jvs.22178. Epub 2022 Sep 15.

DOI:10.4142/jvs.22178
PMID:36259101
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9715393/
Abstract

Domestic poultry are among the non-target species of exposure to fipronil, but limited information is available on the metabolic effects of fipronil exposure in avian. We investigated the comparative capacity of biotransformation of fipronil among chicken, duck, quail, goose, and rat. Interspecies differences in kinetic parameters were observed; the clearance rate calculations (Vmax/Km) indicated that chicken and duck are more efficient in the cytochrome P450-mediated metabolism of fipronil to sulfone than quail, goose and rat. The lower hepatic clearance of fipronil in quail, goose and rat, suggested that fipronil sulfone may serve as a biomarker to indicate fipronil exposure in these species.

摘要

家禽是接触氟虫腈的非靶标物种之一，但有关氟虫腈暴露对禽类的代谢影响的信息有限。我们研究了鸡、鸭、鹌鹑、鹅和大鼠在氟虫腈生物转化方面的比较能力。观察到种间动力学参数的差异；清除率计算（Vmax/Km）表明，鸡和鸭在细胞色素 P450 介导的氟虫腈向砜的代谢中比鹌鹑、鹅和大鼠更有效。鹌鹑、鹅和大鼠中氟虫腈的肝清除率较低，表明氟虫腈砜可能作为这些物种中氟虫腈暴露的生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/9715393/593df2931863/jvs-23-e82-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/9715393/593df2931863/jvs-23-e82-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d7a7/9715393/593df2931863/jvs-23-e82-g001.jpg

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Foods. 2021 Dec 10;10(12):3077. doi: 10.3390/foods10123077.
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3
A comprehensive review of environmental fate and degradation of fipronil and its toxic metabolites.
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Environ Res. 2021 Aug;199:111316. doi: 10.1016/j.envres.2021.111316. Epub 2021 May 11.
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Int J Mol Sci. 2020 Aug 9;21(16):5711. doi: 10.3390/ijms21165711.
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[Analysis of fipronil and metabolites residues distrubution in eggs].[氟虫腈及其代谢物在鸡蛋中的残留分布分析]
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