Zhang Mengyuan, Chen Xiaohang, Zhang Yuan, Zhao Xiangyu, Zhao Jing, Wang Xing
School and Hospital of Stomatology, Shanxi Medical University, Taiyuan, China.
Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Taiyuan, China.
Front Med (Lausanne). 2022 Oct 3;9:978120. doi: 10.3389/fmed.2022.978120. eCollection 2022.
Scars are pathological marks left after an injury heals that inflict physical and psychological harm, especially the great threat to development and aesthetics posed by oral and maxillofacial scars. The differential expression of genes such as transforming growth factor-β, local adherent plaque kinase, and yes-related transcriptional regulators at infancy or the oral mucosa is thought to be the reason of scarless regenerative capacity after tissue defects. Currently, tissue engineering products for defect repair frequently overlook the management of postoperative scars, and inhibitors of important genes alone have negative consequences for the organism. Natural flavonoids have hemostatic, anti-inflammatory, antioxidant, and antibacterial properties, which promote wound healing and have anti-scar properties by interfering with the transmission of key signaling pathways involved in scar formation. The combination of flavonoid-rich drug dressings provides a platform for clinical translation of compounds that aid in drug disintegration, prolonged release, and targeted delivery. Therefore, we present a review of the mechanisms and effects of flavonoids in promoting scar-free regeneration and the application of flavonoid-laden dressings.
瘢痕是损伤愈合后留下的病理性痕迹，会造成生理和心理伤害，尤其是口腔颌面部瘢痕对发育和美观构成的巨大威胁。婴儿期或口腔黏膜中转化生长因子-β、局部黏附斑激酶和Yes相关转录调节因子等基因的差异表达被认为是组织缺损后无瘢痕再生能力的原因。目前，用于缺损修复的组织工程产品常常忽视术后瘢痕的处理，而单独使用重要基因的抑制剂对机体有负面影响。天然黄酮类化合物具有止血、抗炎、抗氧化和抗菌特性，可促进伤口愈合，并通过干扰瘢痕形成所涉及的关键信号通路的传递而具有抗瘢痕特性。富含黄酮类化合物的药物敷料的组合为有助于药物崩解、延长释放和靶向递送的化合物的临床转化提供了一个平台。因此，我们综述了黄酮类化合物促进无瘢痕再生的机制和作用以及含黄酮敷料的应用。
