Department of Animal & Dairy Sciences, University of Wisconsin-Madison, Madison, WI, USA.
Nat Rev Endocrinol. 2022 Dec;18(12):721-722. doi: 10.1038/s41574-022-00759-3.
Host–microorganism circadian dynamics are key contributors to metabolic health. In addition, diet composition and timed feeding affect gut microbiota diurnal rhythms, with high-fat diets altering the composition of the gut microbiota and dampening circadian rhythms throughout the intestine. A recent study shows that time-restricted feeding of a high-fat diet restores the rhythms of small bowel host–microorganism interactions, preventing diet-induced obesity in mice.
宿主-微生物的昼夜节律是影响代谢健康的关键因素。此外，饮食成分和定时喂养会影响肠道微生物群的昼夜节律，高脂肪饮食会改变肠道微生物群的组成，并抑制整个肠道的昼夜节律。最近的一项研究表明，限时喂养高脂肪饮食可以恢复小肠宿主-微生物相互作用的节律，防止小鼠因饮食引起的肥胖。
