Meng Chun-Wang, He Yu-Lin, Peng Cheng, Ding Xing-Jie, Guo Li, Xiong Liang
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; State Key Laboratory Breeding Base of Systematic Research, Development and Utilization of Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
Fitoterapia. 2017 Sep;121:206-211. doi: 10.1016/j.fitote.2017.07.017. Epub 2017 Aug 1.
Five picrotoxane sesquiterpenoids belonging to the unusual dendrobine-type (1 and 4) and the picrotoxinin-type (2, 3, and 5) were isolated from the stems of Dendrobium nobile Lindl. Their structures were established by spectroscopic analyses and physical properties. Compound 1 was a new dendrobine analogue. Although the planar structure of 2 and 3 had been reported, their absolute configurations were first determined by single-crystal X-ray diffraction and circular dichroism. Compound 2 exhibited angiogenesis effect against sunitinib-induced damage on intersegmental blood vessels in Tg (flk1: EGFP) and Tg (fli1: nEGFP) transgenic zebrafish at concentrations of 3.13, 6.25, 12.50, and 25.00μM.
从金钗石斛茎中分离得到了5个属于罕见石蒜碱型（1和4）和印防己毒素型（2、3和5）的木防己烷倍半萜类化合物。通过光谱分析和物理性质确定了它们的结构。化合物1是一种新的石蒜碱类似物。尽管2和3的平面结构已有报道，但它们的绝对构型首次通过单晶X射线衍射和圆二色性确定。化合物2在浓度为3.13、6.25、12.50和25.00μM时，对舒尼替尼诱导的Tg（flk1:EGFP）和Tg（fli1:nEGFP）转基因斑马鱼节间血管损伤具有血管生成作用。
