从白首乌根中提取的三种具有抗胶质瘤作用的新化合物。
Three new compounds with their anti-glioma effects from the roots of Bunge.
作者信息
Yan Yu-Mei, Zou Lin-Jun, Li Min-Hui, Sun Zhao-Cui, Zhang Min, Xu Xu-Dong, Zhang Chun-Hong
机构信息
Baotou Medical College, Inner Mongolia Key Laboratory of Characteristic Geoherbs Resources Protection and Utilization, Inner Mongolia Engineering Research Center of the Planting and Development of Astragalus Membranaceus of the Geoherbs, Baotou, China.
Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, P.R. China.
出版信息
Nat Prod Res. 2023 Aug-Sep;37(17):2817-2823. doi: 10.1080/14786419.2022.2136658. Epub 2022 Oct 20.
Three new compounds, arneatas A-C (-), together with three known compounds (-) were isolated from the roots of Bunge. The structures were established on the basis of extensive spectroscopic data including NMR and HRESIMS. All the new compounds (-) were tested for their cytotoxic activity against two glioma cell lines (U118-MG and U373-MG) after treatment for 48 h. Compound exhibited moderate cytotoxic activity against U118-MG and U373-MG glioma cell lines, with IC values of 10.4 and 17.5 µM, respectively.
从Bunge的根部分离出三种新化合物arneatas A-C（-）以及三种已知化合物（-）。基于包括核磁共振（NMR）和高分辨电喷雾电离质谱（HRESIMS）在内的大量光谱数据确定了其结构。对所有新化合物（-）在处理48小时后针对两种胶质瘤细胞系（U118-MG和U373-MG）进行了细胞毒性活性测试。化合物对U118-MG和U373-MG胶质瘤细胞系表现出中等细胞毒性活性，IC值分别为10.4和17.5微摩尔。
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