Lupia Tommaso, Corcione Silvia, Fornari Valentina, Rizzello Barbara, Bosio Roberta, Brusa Maria Teresa, De Rosa Francesco Giuseppe
Unit of Infectious Diseases, Cardinal Massaia, 14100 Asti, Italy.
Department of Medical Sciences, Infectious Diseases, University of Turin, 10126 Turin, Italy.
Trop Med Infect Dis. 2022 Oct 20;7(10):319. doi: 10.3390/tropicalmed7100319.
The reactivation of latent infection in chronic diseases and immunocompromised hosts is a broad and heterogeneous field in medicine and infectious diseases. We reported one of the first cases of Visceral Leishmaniasis occurring in a Caucasian middle-aged man living in an endemic country (Italy) for infection following secukinumab treatment for psoriatic arthritis. The patient was cured with a Liposomal Amphotericin B (L-AmB, 3 mg/Kg on days 1-5, followed by a dose on days 10, 17, 24, 31 and 38) regimen, after which his anti-interleukin 17 treatment was restarted-without recurrence in the follow-up.
慢性病和免疫功能低下宿主中潜伏感染的再激活是医学和传染病领域一个广泛且异质性的领域。我们报告了首例内脏利什曼病病例，该病例发生在一名居住在流行国家（意大利）的白种中年男性身上，他在接受司库奇尤单抗治疗银屑病关节炎后感染了该病。患者通过脂质体两性霉素B（L-AmB，第1 - 5天3mg/Kg，随后在第10、17、24、31和38天各给药一次）治疗方案治愈，之后重新开始抗白细胞介素17治疗，随访期间未复发。
