FunGlass, Alexander Dubček University of Trenčín, 911 50 Trenčín, Slovakia; Institute of Biomaterials, Department of Material Science and Engineering, University of Erlangen-Nuremberg, 91058 Erlangen, Germany.
FunGlass, Alexander Dubček University of Trenčín, 911 50 Trenčín, Slovakia.
Mater Sci Eng C Mater Biol Appl. 2021 May;124:112050. doi: 10.1016/j.msec.2021.112050. Epub 2021 Mar 24.
In recent years, mesoporous bioactive glass nanoparticles (MBGNPs) have generated great attention in biomedical applications. In this study, cerium and gallium doped MBGNPs were prepared by microemulsion assisted sol-gel method in the binary SiO-CaO system. MBGNPs with spheroidal and pineal shaped morphology were obtained. Nitrogen sorption analysis elucidated the mesoporous structure of synthesized nanoparticles with high specific surface area. X-ray diffraction analysis confirmed the amorphous nature of the nanoparticles. The chemical compositions of all samples were determined by inductively coupled plasma-optical emission spectrometry (ICP-OES), which revealed that the contents of cerium and gallium could be tailored by adjusting the concentrations of the precursors used for the synthesis. All MBGNPs exhibited in vitro bioactivity when immersed in simulated body fluid, except the particles doped with higher amounts than 1 mol% of cerium. MBGNPs showed antibacterial activity against S. aureus and E. coli without exhibiting cytotoxicity towards MG-63 osteoblast-like cells. Mentioned features of the obtained Ce and Ga-doped MBGNPs make them useful for multifunctional applications such as drug delivery carriers or bioactive fillers for bone tissue engineering applications.
近年来，介孔生物活性玻璃纳米颗粒（MBGNPs）在生物医学应用中引起了极大的关注。在这项研究中，采用微乳液辅助溶胶-凝胶法在二元 SiO-CaO 体系中制备了铈和镓掺杂的 MBGNPs。得到了具有球状和松果状形态的 MBGNPs。氮气吸附分析阐明了合成纳米粒子具有高比表面积的介孔结构。X 射线衍射分析证实了纳米粒子的非晶态性质。所有样品的化学成分均通过电感耦合等离子体-光学发射光谱法（ICP-OES）确定，结果表明，通过调整用于合成的前体浓度，可以调整铈和镓的含量。所有 MBGNPs 在浸入模拟体液中时均表现出体外生物活性，除了掺杂高于 1 mol%铈的颗粒外。MBGNPs 对金黄色葡萄球菌和大肠杆菌具有抗菌活性，而对 MG-63 成骨样细胞没有细胞毒性。所获得的 Ce 和 Ga 掺杂 MBGNPs 的这些特性使它们可用于多功能应用，例如药物输送载体或用于骨组织工程应用的生物活性填料。
