Ullah Asad, Mu Jing, Wang Fenghuan, Chan Malik Wajid Hussain, Yin Xian, Liao Yonghong, Mirani Zulfiqar Ali, Sebt-E-Hassan Syed, Aslam Sadar, Naveed Muhammad, Khan Muhammad Naseem, Khatoon Zakia, Kazmi Mohib Reza
Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology & Business University (BTBU), Beijing 100048, China.
School of Light Industry, Beijing Technology & Business University (BTBU), Beijing 100048, China.
Antioxidants (Basel). 2022 Sep 27;11(10):1916. doi: 10.3390/antiox11101916.
Selenium nanoparticles (SeNPs) can be produced by biogenic, physical, and chemical processes. The physical and chemical processes have hazardous effects. However, biogenic synthesis (by microorganisms) is an eco-friendly and economical technique that is non-toxic to human and animal health. The mechanism for biogenic SeNPs from microorganisms is still not well understood. Over the past two decades, extensive research has been conducted on the nutritional and therapeutic applications of biogenic SeNPs. The research revealed that biogenic SeNPs are considered novel competitors in the pharmaceutical and food industries, as they have been shown to be virtually non-toxic when used in medical practice and as dietary supplements and release only trace amounts of Se ions when ingested. Various pathogenic and probiotic/nonpathogenic bacteria are used for the biogenic synthesis of SeNPs. However, in the case of biosynthesis by pathogenic bacteria, extraction and purification techniques are required for further useful applications of these biogenic SeNPs. This review focuses on the applications of SeNPs (derived from probiotic/nonpathogenic organisms) as promising anticancer agents. This review describes that SeNPs derived from probiotic/nonpathogenic organisms are considered safe for human consumption. These biogenic SeNPs reduce oxidative stress in the human body and have also been shown to be effective against breast, prostate, lung, liver, and colon cancers. This review provides helpful information on the safe use of biogenic SeNPs and their economic importance for dietary and therapeutic purposes, especially as anticancer agents.
硒纳米颗粒（SeNPs）可以通过生物、物理和化学过程来制备。物理和化学过程具有有害影响。然而，生物合成（通过微生物）是一种生态友好且经济的技术，对人类和动物健康无毒。微生物合成生物源硒纳米颗粒的机制仍未完全清楚。在过去的二十年里，人们对生物源硒纳米颗粒的营养和治疗应用进行了广泛的研究。研究表明，生物源硒纳米颗粒在制药和食品工业中被视为新型竞争者，因为它们在医学实践中用作膳食补充剂时几乎无毒，摄入后仅释放微量的硒离子。各种致病细菌和益生菌/非致病细菌都可用于生物合成硒纳米颗粒。然而，对于致病细菌的生物合成，这些生物源硒纳米颗粒的进一步有效应用需要提取和纯化技术。本综述重点关注源自益生菌/非致病生物的硒纳米颗粒作为有前景的抗癌剂的应用。本综述描述了源自益生菌/非致病生物的硒纳米颗粒被认为对人类食用是安全的。这些生物源硒纳米颗粒可减轻人体的氧化应激，并且已被证明对乳腺癌、前列腺癌、肺癌、肝癌和结肠癌有效。本综述提供了有关生物源硒纳米颗粒安全使用及其在饮食和治疗目的（尤其是作为抗癌剂）方面的经济重要性的有用信息。
