Ataollahi Farshid, Amirheidari Bagher, Amirheidari Zohreh, Ataollahi Mahshid
Extremophile and Productive Microorganisms Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Biotechnol Lett. 2025 Jan 18;47(1):18. doi: 10.1007/s10529-024-03559-z.
Selenium is an essential element with various industrial and medical applications, hence the current considerable attention towards the genesis and utilization of SeNPs. SeNPs and other nanoparticles could be achieved via physical and chemical methods, but these methods would not only require expensive equipment and specific reagents but are also not always environment friendly. Biogenesis of SeNPs could therefore be considered as a less troublesome alternative, which opens an excellent window to the selenium and nanoparticles' world. bSeNPs have proved to exert higher bioavailability, lower toxicity, and broader utility as compared to their non-bio counterparts. Many researchers have reported promising features of bSeNP such as anti-oxidant and anti-inflammatory, in vitro and in vivo. Considering this, bSeNPs have been tried as effective agents for health disorders, especially as constituents of probiotics. This article briefly reviews selenium, selenium nanoparticles, Se-enriched probiotics, and bSeNPs' usage in an array of health disorders. Obviously, there are very many articles on bSeNPs, but we wanted to summarize studies on prominent bSeNPs features published in the twenty-first century. This review is hoped to give an outlook to researchers for their future investigations, ultimately serving better care of health disorders.
硒是一种具有多种工业和医学应用的必需元素，因此目前人们对硒纳米粒子（SeNPs）的生成和利用给予了相当大的关注。SeNPs和其他纳米粒子可以通过物理和化学方法获得，但这些方法不仅需要昂贵的设备和特定的试剂，而且并不总是环保的。因此，SeNPs的生物合成可以被视为一种麻烦较少的替代方法，这为硒和纳米粒子的世界打开了一扇绝佳的窗口。与非生物合成的SeNPs相比，生物合成的SeNPs（bSeNPs）已被证明具有更高的生物利用度、更低的毒性和更广泛的用途。许多研究人员报告了bSeNP在体外和体内具有抗氧化、抗炎等有前景的特性。考虑到这一点，bSeNPs已被尝试作为治疗健康疾病的有效药物，尤其是作为益生菌的成分。本文简要综述了硒、硒纳米粒子、富硒益生菌以及bSeNPs在一系列健康疾病中的应用。显然，关于bSeNPs的文章非常多，但我们想总结21世纪发表的关于bSeNPs突出特性的研究。希望这篇综述能为研究人员的未来研究提供一个展望，最终更好地治疗健康疾病。
