Narayanan Zareen, Glick Bernard R
Division of Biological Sciences, School of STEM, University of Washington, Bothell, WA 98011, USA.
Department of Biology, University of Waterloo, Waterloo, ON N2L3G1, Canada.
Microorganisms. 2022 Oct 11;10(10):2008. doi: 10.3390/microorganisms10102008.
There is an increasing interest in the use of beneficial microorganisms as alternatives to chemically synthesized or plant-derived molecules to produce therapeutic agents. Bacterial endophytes are plant-associated microorganisms that can colonize different parts of living plants without causing any diseases. Diverse endophytic bacteria possess the ability to synthesize a wide range of secondary metabolites with unique chemical structures that have been exploited for their anti-microbial, antiviral, anti-cancer, and anti-inflammatory properties. Additionally, production of these bioactive compounds can also benefit the host plant as they may play a significant role in a plant's interaction with the environment for adaptation and defense. As a result of their significant impact as curative compounds or as precursors to produce new drugs, the biotechnological possibilities of secondary metabolites derived from endophytic bacteria are immense.
人们越来越关注使用有益微生物来替代化学合成或植物衍生分子以生产治疗剂。细菌内生菌是与植物相关的微生物，它们可以定殖在活植物的不同部位而不引起任何疾病。多种内生细菌具有合成各种具有独特化学结构的次生代谢产物的能力，这些次生代谢产物因其抗菌、抗病毒、抗癌和抗炎特性而得到利用。此外，这些生物活性化合物的产生也可能使宿主植物受益，因为它们可能在植物与环境的相互作用中发挥重要作用，以实现适应和防御。由于它们作为治疗化合物或生产新药的前体具有重大影响，内生细菌衍生的次生代谢产物的生物技术潜力巨大。
