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整合代谢组学和脂质组学策略揭示植物生长延缓剂多效唑改变桔梗化学成分的作用模式。

Integrated Metabolome and Lipidome Strategy to Reveal the Action Pattern of Paclobutrazol, a Plant Growth Retardant, in Varying the Chemical Constituents of Platycodon Root.

机构信息

NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine, Shanghai Institute for Food and Drug Control, Shanghai 201203, China.

School of Pharmacy, Yantai University, Yantai 264005, China.

出版信息

Molecules. 2022 Oct 14;27(20):6902. doi: 10.3390/molecules27206902.

DOI:10.3390/molecules27206902
PMID:36296498
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9609321/
Abstract

Platycodon root, a medicinal food homology species which has been used in Asian countries for hundreds of years, is now widely cultivated in China. Treatment with paclobutrazol, a typical plant growth retardant, has raised uncertainties regarding the quality of Platycodon root, which have been rarely investigated. In the present study, metabolomic and lipidomic differences were revealed by ultra-high performance liquid chromatography coupled to ion mobility-quadrupole time of flight mass spectrometry (UPLC-IM-QTOF-MS). A significant decrease of platycodigenin-type saponins was observed in the paclobutrazol-treated sample. Carrying out a comprehensive quantitative analysis, the contents of total saponins and saccharides were determined to illustrate the mode of action of paclobutrazol on Platycodon root. This study demonstrated an exemplary research model in explaining how the exogenous matter influences the chemical properties of medicinal plants, and therefore might provide insights into the reasonable application of plant growth regulators.

摘要

桔梗，一种药用同源植物，在亚洲国家已经使用了数百年，现在在中国广泛种植。使用典型的植物生长调节剂多效唑处理桔梗后，其质量存在不确定性，这方面的研究很少。在本研究中，通过超高效液相色谱-离子淌度-四极杆飞行时间质谱联用技术（UPLC-IM-QTOF-MS）揭示了代谢组学和脂质组学的差异。在多效唑处理的样品中，观察到了显著减少的桔梗皂苷型皂苷。通过进行全面的定量分析，测定了总皂苷和糖的含量，说明了多效唑对桔梗的作用模式。本研究展示了一个典范的研究模式，解释了外源物质如何影响药用植物的化学性质，因此可能为植物生长调节剂的合理应用提供了思路。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/d9537a6d9206/molecules-27-06902-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/b5c6938fb128/molecules-27-06902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/fae0409c780b/molecules-27-06902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/4090a7cfe69d/molecules-27-06902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/625eda39ea83/molecules-27-06902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/5dada602532d/molecules-27-06902-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/d9537a6d9206/molecules-27-06902-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/b5c6938fb128/molecules-27-06902-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/fae0409c780b/molecules-27-06902-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/4090a7cfe69d/molecules-27-06902-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/625eda39ea83/molecules-27-06902-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/5dada602532d/molecules-27-06902-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf8c/9609321/d9537a6d9206/molecules-27-06902-g006.jpg

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