Chen Daqin, Li Qiannan, Zhang Huimin, Kou Fang, Li Qiang, Lyu Chunming, Wei Hai
Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Front Pharmacol. 2022 Oct 10;13:1025602. doi: 10.3389/fphar.2022.1025602. eCollection 2022.
Hypertrophic scar (HS) is a typical pathological response during skin injury, which can lead to pain, itching, and contracture in patients and even affect their physical and mental health. The complexity of the wound healing process leads to the formation of HS affected by many factors. Several treatments are available for HS, whereas some have more adverse reactions and can even cause new injuries with exacerbated scarring. Traditional Chinese Medicine (TCM) has a rich source, and most botanical drugs have few side effects, providing new ideas and methods for treating HS. This paper reviews the formation process of HS, the therapeutic strategy for HS, the research progress of TCM with its relevant mechanisms in the treatment of HS, and the related new drug delivery system of TCM, aiming to provide ideas for further research of botanical compounds in the treatment of HS, to promote the discovery of more efficient botanical candidates for the clinical treatment of HS, to accelerate the development of the new drug delivery system and the final clinical application, and at the same time, to promote the research on the anti-HS mechanism of multiherbal preparations (Fufang), to continuously improve the quality control and safety and effectiveness of anti-HS botanical drugs in clinical application.
增生性瘢痕（HS）是皮肤损伤时典型的病理反应，可导致患者疼痛、瘙痒和挛缩，甚至影响其身心健康。伤口愈合过程的复杂性导致HS的形成受多种因素影响。目前有多种治疗HS的方法，然而有些方法不良反应较多，甚至会造成新的损伤并加重瘢痕形成。中药资源丰富，大多数植物药副作用较少，为HS的治疗提供了新思路和方法。本文综述了HS的形成过程、HS的治疗策略、中药治疗HS的研究进展及其相关机制，以及中药相关的新型给药系统，旨在为植物化合物治疗HS的进一步研究提供思路，促进发现更多高效的植物候选药物用于HS的临床治疗，加速新型给药系统的开发及最终临床应用，同时推动对多味中药复方抗HS机制的研究，不断提高抗HS植物药临床应用的质量控制及安全性和有效性。
