Ryon Krista A, Tierney Braden T, Frolova Alina, Kahles Andre, Desnues Christelle, Ouzounis Christos, Gibas Cynthis, Bezdan Daniela, Deng Youping, He Ding, Dias-Neto Emmanuel, Elhaik Eran, Afshin Evan, Grills George, Iraola Gregorio, Suzuki Haruo, Werner Johannes, Udekwu Klas, Schriml Lynn, Bhattacharyya Malay, Oliveira Manuela, Zambrano Maria Mercedes, Hazrin-Chong Nur Hazlin, Osuolale Olayinka, Łabaj Paweł P, Tiasse Prisca, Rapuri Sampath, Borras Silvia, Pozdniakova Sofya, Shi Tieliu, Sezerman Ugur, Rodo Xavier, Sezer Zehra Hazal, Mason Christopher E
Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY USA.
Weill Cornell Medicine, New York, NY, USA.
iScience. 2022 Oct 20;25(11):104993. doi: 10.1016/j.isci.2022.104993. eCollection 2022 Nov 18.
The MetaSUB Consortium, founded in 2015, is a global consortium with an interdisciplinary team of clinicians, scientists, bioinformaticians, engineers, and designers, with members from more than 100 countries across the globe. This network has continually collected samples from urban and rural sites including subways and transit systems, sewage systems, hospitals, and other environmental sampling. These collections have been ongoing since 2015 and have continued when possible, even throughout the COVID-19 pandemic. The consortium has optimized their workflow for the collection, isolation, and sequencing of DNA and RNA collected from these various sites and processing them for metagenomics analysis, including the identification of SARS-CoV-2 and its variants. Here, the Consortium describes its foundations, and its ongoing work to expand on this network and to focus its scope on the mapping, annotation, and prediction of emerging pathogens, mapping microbial evolution and antibiotic resistance, and the discovery of novel organisms and biosynthetic gene clusters.
MetaSUB联盟成立于2015年，是一个全球性联盟，拥有一支由临床医生、科学家、生物信息学家、工程师和设计师组成的跨学科团队，其成员来自全球100多个国家。该网络不断从城市和农村地区收集样本，包括地铁和交通系统、污水系统、医院以及其他环境采样点。自2015年以来，这些样本收集工作一直在进行，并且在可能的情况下持续进行，甚至在新冠疫情期间也未中断。该联盟优化了从这些不同地点收集DNA和RNA的流程，包括样本采集、分离和测序，并对其进行宏基因组学分析处理，包括鉴定新冠病毒及其变体。在此，该联盟介绍了其基础情况，以及为扩展这个网络、将工作重点放在新兴病原体的图谱绘制、注释和预测、绘制微生物进化和抗生素耐药性图谱以及发现新生物体和生物合成基因簇等方面正在开展的工作。
