儿童 COVID-19 患者的生物标志物变化：单中心数据库的回顾性研究。
Biomarker Changes in Pediatric Patients With COVID-19: A Retrospective Study from a Single Center Database.
机构信息
Department of Medical Disciplines, Faculty of Medicine and Pharmacy, University of Oradea, Oradea, Romania.
Department of Pediatrics, County Clinical Emergency Hospital of Oradea, Oradea, Romania.
出版信息
In Vivo. 2022 Nov-Dec;36(6):2813-2822. doi: 10.21873/invivo.13019.
Abstract
BACKGROUND/AIM: The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for generating a global pandemic with deadly consequences and life changes worldwide. With the appearance of the new variants of the virus, clinical manifestations have been reported in the pediatric population, some with severe evolution. The aim of this study was to identify the laboratory parameters necessary to establish an effective therapy.
PATIENTS AND METHODS
In the period from August 2020 to September 2021, 234 pediatric patients met the inclusion criteria and were selected for the study. After confirming the COVID-19 diagnosis, laboratory parameters were analyzed and compared to the severity of the illness.
RESULTS
Thrombocytopenia (p<0.001), leukocytosis (p<0.001), and lymphopenia (p<0.001) correlated with the severity of the disease. Also, D-dimer values were closely monitored due to the high association of this parameter with an unsatisfactory prognosis and a severe form of the disease.
CONCLUSION
The D-dimer values and complete blood count are useful parameters in COVID-19 evaluation in children.
摘要
背景/目的：新型严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）是导致具有致命后果和全球生活变化的全球大流行的罪魁祸首。随着病毒新变体的出现，儿科人群中报告了临床表现，其中一些病情严重。本研究旨在确定建立有效治疗所需的实验室参数。
患者和方法
在 2020 年 8 月至 2021 年 9 月期间，234 名符合纳入标准的儿科患者被选中进行研究。在确认 COVID-19 诊断后，分析了实验室参数并与疾病严重程度进行了比较。
结果
血小板减少症（p<0.001）、白细胞增多症（p<0.001）和淋巴细胞减少症（p<0.001）与疾病严重程度相关。此外，由于该参数与预后不良和疾病严重形式高度相关，因此密切监测 D-二聚体值。
结论
D-二聚体值和全血细胞计数是 COVID-19 儿童评估中有用的参数。
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