苯妥英钠所致的IgA降低。
Phenytoin-induced IgA depression.
作者信息
Ruff M E, Pincus L G, Sampson H A
出版信息
Am J Dis Child. 1987 Aug;141(8):858-61. doi: 10.1001/archpedi.1987.04460080044024.
In a survey of 1011 pediatric patients with seizure disorders, 93 children (9.2%) were found to have depressed serum IgA concentrations when compared with age-matched controls; 27 of these values were less than 0.1 g/L (less than 10 mg/dL). Two thirds (64/93) of these patients were being treated with phenytoin, and ten had been previously treated with phenytoin. No relationship between IgA deficiency and serum phenytoin concentration nor use of other anticonvulsant medications was found. The prevalence of phenytoin-induced IgA depression was similar in patients with "primary" or "secondary" seizure disorders. Approximately 40% of the patients with low serum IgA concentrations had mild to moderate depression of serum IgG and/or IgM concentrations when compared with age-matched controls.
在一项针对1011名癫痫患儿的调查中，与年龄匹配的对照组相比，发现93名儿童（9.2%）血清IgA浓度降低；其中27个值低于0.1g/L（低于10mg/dL）。这些患者中有三分之二（64/93）正在接受苯妥英治疗，10名患者此前曾接受过苯妥英治疗。未发现IgA缺乏与血清苯妥英浓度之间的关系，也未发现使用其他抗惊厥药物与IgA缺乏有关。苯妥英引起的IgA降低在“原发性”或“继发性”癫痫患者中的发生率相似。与年龄匹配的对照组相比，约40%血清IgA浓度低的患者血清IgG和/或IgM浓度有轻度至中度降低。
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