• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

宿主生物标志物反映中度2019冠状病毒病患者的预后：一项前瞻性队列研究。

Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study.

作者信息

Chandna Arjun, Mahajan Raman, Gautam Priyanka, Mwandigha Lazaro, Kumar Pragya, Varghese George M, Koshiaris Constantinos, Lubell Yoel, Burza Sakib

机构信息

Cambodia Oxford Medical Research Unit, Angkor Hospital for Children, Siem Reap, Cambodia.

Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, United Kingdom.

出版信息

Open Forum Infect Dis. 2022 Oct 6;9(10):ofac526. doi: 10.1093/ofid/ofac526. eCollection 2022 Oct.

DOI:10.1093/ofid/ofac526
PMID:36320192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9605705/
Abstract

Efficient resource allocation is essential for effective pandemic response. We measured host biomarkers in 420 patients presenting with moderate coronavirus disease 2019 and found that different biomarkers predict distinct clinical outcomes. Interleukin (IL)-1ra, IL-6, IL-10, and IL-8 exhibit dose-response relationships with subsequent disease progression and could potentially be useful for multiple use-cases.

摘要

高效的资源分配对于有效的疫情应对至关重要。我们对420例中度2019冠状病毒病患者的宿主生物标志物进行了测量，发现不同的生物标志物可预测不同的临床结果。白细胞介素（IL）-1ra、IL-6、IL-10和IL-8与随后的疾病进展呈现剂量反应关系，并且可能对多种应用场景有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c63/9605705/6e8a723ca4a5/ofac526f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c63/9605705/6e8a723ca4a5/ofac526f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c63/9605705/6e8a723ca4a5/ofac526f1.jpg

相似文献

1
Host Biomarkers Reflect Prognosis in Patients Presenting With Moderate Coronavirus Disease 2019: A Prospective Cohort Study.宿主生物标志物反映中度2019冠状病毒病患者的预后：一项前瞻性队列研究。
Open Forum Infect Dis. 2022 Oct 6;9(10):ofac526. doi: 10.1093/ofid/ofac526. eCollection 2022 Oct.
2
Signs and symptoms to determine if a patient presenting in primary care or hospital outpatient settings has COVID-19.在基层医疗机构或医院门诊环境中，如果患者出现以下症状和体征，可判断其是否患有 COVID-19。
Cochrane Database Syst Rev. 2022 May 20;5(5):CD013665. doi: 10.1002/14651858.CD013665.pub3.
3
[Guidelines for the prevention and management of bronchial asthma (2024 edition)].[支气管哮喘防治指南（2024年版）]
Zhonghua Jie He He Hu Xi Za Zhi. 2025 Mar 12;48(3):208-248. doi: 10.3760/cma.j.cn112147-20241013-00601.
4
Prophylactic anticoagulants for non-hospitalised people with COVID-19.COVID-19 非住院患者的预防性抗凝治疗。
Cochrane Database Syst Rev. 2023 Aug 16;8(8):CD015102. doi: 10.1002/14651858.CD015102.pub2.
5
Physical interventions to interrupt or reduce the spread of respiratory viruses.物理干预措施以阻断或减少呼吸道病毒的传播。
Cochrane Database Syst Rev. 2023 Jan 30;1(1):CD006207. doi: 10.1002/14651858.CD006207.pub6.
6
Development of a metabolome-based respiratory infection prognostic during COVID-19 arrival.在新冠疫情到来期间基于代谢组学的呼吸道感染预后研究进展
mBio. 2025 Jan 8;16(1):e0334323. doi: 10.1128/mbio.03343-23. Epub 2024 Nov 22.
7
Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review.乳腺密度、内分泌治疗与乳腺癌风险：预后和预测生物标志物综述。
Cochrane Database Syst Rev. 2021 Oct 26;10(10):CD013091. doi: 10.1002/14651858.CD013091.pub2.
8
Biomarkers as point-of-care tests to guide prescription of antibiotics in patients with acute respiratory infections in primary care.生物标志物作为即时检验手段，用于指导基层医疗中急性呼吸道感染患者的抗生素处方。
Cochrane Database Syst Rev. 2014 Nov 6(11):CD010130. doi: 10.1002/14651858.CD010130.pub2.
9
Systemic treatments for metastatic cutaneous melanoma.转移性皮肤黑色素瘤的全身治疗
Cochrane Database Syst Rev. 2018 Feb 6;2(2):CD011123. doi: 10.1002/14651858.CD011123.pub2.
10
Pharmacotherapies for sleep disturbances in dementia.痴呆症睡眠障碍的药物治疗
Cochrane Database Syst Rev. 2016 Nov 16;11(11):CD009178. doi: 10.1002/14651858.CD009178.pub3.

引用本文的文献

1
Soluble triggering receptor expressed on myeloid cells 1 (sTREM-1) predicts mortality in patients with febrile illness in southern Mozambique.髓系细胞表面表达的可溶性触发受体1（sTREM-1）可预测莫桑比克南部发热性疾病患者的死亡率。
Commun Med (Lond). 2025 Jul 25;5(1):310. doi: 10.1038/s43856-025-01014-2.
2
Host Response Markers of Inflammation and Endothelial Activation Associated with COVID-19 Severity and Mortality: A GeoSentinel Prospective Observational Cohort.与 COVID-19 严重程度和死亡率相关的宿主炎症反应标志物和血管内皮激活：GeoSentinel 前瞻性观察队列研究。
Viruses. 2024 Oct 15;16(10):1615. doi: 10.3390/v16101615.
3

本文引用的文献

1
Facilitating Safe Discharge Through Predicting Disease Progression in Moderate Coronavirus Disease 2019 (COVID-19): A Prospective Cohort Study to Develop and Validate a Clinical Prediction Model in Resource-Limited Settings.通过预测中度 2019 冠状病毒病（COVID-19）疾病进展来促进安全出院：在资源有限环境中开发和验证临床预测模型的前瞻性队列研究。
Clin Infect Dis. 2022 Aug 24;75(1):e368-e379. doi: 10.1093/cid/ciac224.
2
Risk-stratification of febrile African children at risk of sepsis using sTREM-1 as basis for a rapid triage test.应用 sTREM-1 对疑似脓毒症发热非洲儿童进行风险分层，作为快速分诊试验的依据。
Nat Commun. 2021 Nov 25;12(1):6832. doi: 10.1038/s41467-021-27215-6.
3
Situational Analysis of Healthcare and Medical Diagnostic Testing Facility Availability in Selected Blocks of Muzaffarpur District, Bihar, India: A Cross-Sectional Study.
印度比哈尔邦穆扎法尔布尔区部分街区医疗保健与医疗诊断检测设施可及性的现状分析：一项横断面研究
Cureus. 2023 Sep 26;15(9):e46037. doi: 10.7759/cureus.46037. eCollection 2023 Sep.
4
Defining the role of host biomarkers in the diagnosis and prognosis of the severity of childhood pneumonia: a prospective cohort study.定义宿主生物标志物在儿童肺炎严重程度的诊断和预后中的作用：一项前瞻性队列研究。
Sci Rep. 2023 Jul 25;13(1):12024. doi: 10.1038/s41598-023-38731-4.
Anticipating the future: prognostic tools as a complementary strategy to improve care for patients with febrile illnesses in resource-limited settings.
预见未来：预测工具作为一种补充策略，以改善资源有限环境中发热疾病患者的护理。
BMJ Glob Health. 2021 Jul;6(7). doi: 10.1136/bmjgh-2021-006057.
4
Oxygen supplies and COVID-19 mortality in Africa.非洲的氧气供应与新冠疫情死亡率
Lancet Respir Med. 2021 Apr;9(4):e39. doi: 10.1016/S2213-2600(21)00087-4. Epub 2021 Feb 10.
5
COVID-19 risk stratification algorithms based on sTREM-1 and IL-6 in emergency department.基于 sTREM-1 和 IL-6 的急诊科 COVID-19 风险分层算法。
J Allergy Clin Immunol. 2021 Jan;147(1):99-106.e4. doi: 10.1016/j.jaci.2020.10.001. Epub 2020 Oct 9.
6
An inflammatory cytokine signature predicts COVID-19 severity and survival.炎症细胞因子特征可预测 COVID-19 严重程度和存活情况。
Nat Med. 2020 Oct;26(10):1636-1643. doi: 10.1038/s41591-020-1051-9. Epub 2020 Aug 24.
7
Dexamethasone in Hospitalized Patients with Covid-19.地塞米松在 COVID-19 住院患者中的应用。
N Engl J Med. 2021 Feb 25;384(8):693-704. doi: 10.1056/NEJMoa2021436. Epub 2020 Jul 17.
8
Predictors of progression from moderate to severe coronavirus disease 2019: a retrospective cohort.从中度到重度 2019 冠状病毒病进展的预测因素：一项回顾性队列研究。
Clin Microbiol Infect. 2020 Oct;26(10):1400-1405. doi: 10.1016/j.cmi.2020.06.033. Epub 2020 Jul 2.
9
sTREM-1 predicts mortality in hospitalized patients with infection in a tropical, middle-income country.sTREM-1 可预测热带地区中等收入国家感染住院患者的死亡率。
BMC Med. 2020 Jul 1;18(1):159. doi: 10.1186/s12916-020-01627-5.
10
A minimal common outcome measure set for COVID-19 clinical research.用于 COVID-19 临床研究的最小通用结局指标集。
Lancet Infect Dis. 2020 Aug;20(8):e192-e197. doi: 10.1016/S1473-3099(20)30483-7. Epub 2020 Jun 12.