Department of Immunology, Chinese Academy of Medical Sciences (CAMS) Key Laboratory of T Cell and Cancer Immunotherapy, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences (CAMS) and School of Basic Medicine, Peking Union Medical College, Beijing, China.
Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy, Changzhou, China.
Front Immunol. 2022 Oct 17;13:996103. doi: 10.3389/fimmu.2022.996103. eCollection 2022.
Spondyloarthritis (SpA) refers to a group of diseases with inflammation in joints and spines. In this family, ankylosing spondylitis (AS) is a rare but classic form that mainly involves the spine and sacroiliac joint, leading to the loss of flexibility and fusion of the spine. Compared to other diseases in SpA, AS has a very distinct hereditary disposition and pattern of involvement, and several hypotheses about its etiopathogenesis have been proposed. In spite of significant advances made in Th17 dynamics and AS treatment, the underlying mechanism remains concealed. To this end, we covered several topics, including the nature of the immune response, the microenvironment in the articulation that is behind the disease's progression, and the split between the hypotheses and the evidence on how the intestine affects arthritis. In this review, we describe the current findings of AS and SpA, with the aim of providing an integrated view of the initiation of inflammation and the development of the disease.
脊柱关节炎（SpA）是一组以关节和脊柱炎症为特征的疾病。在这个家族中，强直性脊柱炎（AS）是一种罕见但典型的形式，主要涉及脊柱和骶髂关节，导致脊柱失去灵活性和融合。与 SpA 中的其他疾病相比，AS 具有非常明显的遗传倾向和受累模式，并且已经提出了几种关于其发病机制的假说。尽管在 Th17 动力学和 AS 治疗方面取得了重大进展，但潜在机制仍不清楚。为此，我们涵盖了几个主题，包括免疫反应的性质、关节内的微环境，以及假设与肠道如何影响关节炎的证据之间的分歧。在这篇综述中，我们描述了 AS 和 SpA 的当前发现，旨在提供炎症起始和疾病发展的综合观点。
