School of Food Industrial Sciences, Department of Food Resource Development, Miyagi University, 2-2-1 Hatatate, Taihaku-Ku, Sendai, Miyagi, 982-0215, Japan.
Department of Chemistry, Tohoku University, Sendai, Miyagi, Japan.
Sci Rep. 2022 Nov 4;12(1):18653. doi: 10.1038/s41598-022-21436-5.
The Fukushima Daiichi Nuclear Power Plant accident led to contamination with radioactive cesium in an extensive environment in Japan in 2011. We evaluated the concentration of radioactive cesium in the skeletal muscles of 22 wild boars and the expression of IFN-γ, TLR3, and CyclinG1 in the small intestine and compared them with those of wild boar samples collected from Hyogo prefecture. The average Cs radioactivity concentration in wild boars in the ex-evacuation zone was 470 Bq/kg. Most of samples still showed radioactivity concentration that exceeded the regulatory limit for foods, but the dose remarkably decreased compared with samples just after the accident. IFN-γ expression was significantly higher in wild boars in the ex-evacuation zone than in samples from Hyogo prefecture. TLR3 expression was also upregulated. CyclinG1 expression also tended to be high. Hence, wild boars might have received some effects of low-dose radiation, and immune cells were activated to some extent. However, pathological examination revealed no inflammatory cell infiltration or pathological damage in the small intestine of wild boars in the ex-evacuation area. Long-term monitoring would be necessary, but we consider that the living body responds appropriately to a stimulus from a contaminated environment.
2011 年福岛第一核电站事故导致日本大范围环境遭受放射性铯污染。本研究检测了 22 头野猪骨骼肌中放射性铯的浓度，以及其小肠中 IFN-γ、TLR3 和 CyclinG1 的表达，并与兵库县野猪样本进行了比较。撤离区野猪的 Cs 放射性平均浓度为 470 Bq/kg。大多数样本仍显示放射性浓度超过食品监管限值，但与事故刚发生后的样本相比，剂量显著下降。撤离区野猪的 IFN-γ 表达明显高于兵库县的样本。TLR3 的表达也上调。CyclinG1 的表达也有升高的趋势。因此，野猪可能受到了低剂量辐射的影响，免疫细胞在一定程度上被激活。然而，对撤离区野猪的小肠进行病理检查未发现炎性细胞浸润或病理损伤。需要进行长期监测，但我们认为生物体对污染环境的刺激会做出适当的反应。
