Shayani Rad Maryam, Moohebati Mohsen, Mohajeri Seyed Ahmad
Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Student Research Committee (SRC), Mashhad University of Medical Sciences, Mashhad, Iran.
Inflammopharmacology. 2023 Feb;31(1):395-410. doi: 10.1007/s10787-022-01083-y. Epub 2022 Nov 5.
Anxiety and depression are crucial public health issues, affecting the rising in hospitalizations and death. Anxiety and depression can worsen hypertension and vice versa.
The current study has investigated the effects of celery seed extract, as a drug supplement, with the active ingredient of 3-n-butylphthalide, on mental problems primarily anxiety and secondary depression in hypertensive patients.
The current study was a randomized, triple-blind, placebo-controlled, cross-over, 4-week clinical trial with a 4-week washout period. Fifty hypertensive patients received 4 placebo or celery seed extract capsules (1.34 g per day) for 4 weeks as a supplement to their usual medication regimen. The blood pressure parameters were assessed using 24-h ambulatory blood pressure monitoring device. Anxiety and depression and their wide range of symptoms were evaluated using Beck anxiety and depression inventories (BAI and BDI).
In the celery treatment step, the mean reduction in BAI and BDI scores were 6.78 (P < 0.001) and 3.63 (P < 0.01), respectively. Some symptoms of anxiety including unable to relax, nervousness, numbness, dizziness, flushed face, sweating, and breathing difficulty were significantly improved by celery consumption (P < 0.001). Celery could decrease symptoms of depression such as sadness, crying, loss of energy, insomnia, irritability, fatigue, loss of interest in sex, and punishment feeling (P < 0.01). The mean reduction in blood pressure parameters was also significant during celery therapy (P < 0.001).
The psychometric properties of anxiety and depression were investigated and the results were promising. The results indicated the anti-anxiety and anti-depressive properties of celery seed extract as a supplement in hypertensive patients.
Registry name: Iranian Registry of Clinical Trials (IRCT), Registration number: IRCT20130418013058N8, Registration link: https://www.irct.ir/trial/30021 . The study was carried out between 2018-09-21 and 2020-07-20.
焦虑和抑郁是重要的公共卫生问题，影响着住院率和死亡率的上升。焦虑和抑郁会加重高血压，反之亦然。
本研究调查了芹菜籽提取物（一种药物补充剂，其活性成分是3-正丁基苯酞）对高血压患者主要的焦虑及继发的抑郁等心理问题的影响。
本研究是一项随机、三盲、安慰剂对照、交叉的4周临床试验，有4周的洗脱期。50名高血压患者作为其常规药物治疗方案的补充，接受4周的4粒安慰剂或芹菜籽提取物胶囊（每天1.34克）。使用24小时动态血压监测设备评估血压参数。使用贝克焦虑和抑郁量表（BAI和BDI）评估焦虑、抑郁及其广泛的症状。
在芹菜治疗阶段，BAI和BDI评分的平均降低分别为6.78（P<0.001）和3.63（P<0.01）。食用芹菜可显著改善一些焦虑症状，包括无法放松、紧张、麻木、头晕、脸红、出汗和呼吸困难（P<0.001）。芹菜可减轻抑郁症状，如悲伤、哭泣、精力丧失、失眠、易怒、疲劳、对性失去兴趣和受惩罚感（P<0.01）。在芹菜治疗期间，血压参数的平均降低也很显著（P<0.001）。
对焦虑和抑郁的心理测量特性进行了研究，结果很有前景。结果表明芹菜籽提取物作为高血压患者的补充剂具有抗焦虑和抗抑郁特性。
注册名称：伊朗临床试验注册中心（IRCT），注册号：IRCT20130418013058N8，注册链接：https://www.irct.ir/trial/30021 。该研究于2018年9月21日至2020年7月20日进行。
