Herbal Medicine Research Centre, Institute for Medical Research, Ministry of Health, Shah Alam 40170, Malaysia.
School of Pharmacy, Monash University Malaysia, Subang Jaya 47500, Malaysia.
Molecules. 2023 Aug 2;28(15):5824. doi: 10.3390/molecules28155824.
is an indigenous plant in the family Apiaceae, or Umbelliferae, that contains many active compounds. It has been used traditionally to treat arthritic conditions, gout, and urinary infections. The authors conducted a scoping review to assess the quality of available evidence on the overall effects of celery when treating neurological disorders. A systematic search was performed using predetermined keywords in selected electronic databases. The 26 articles included upon screening consisted of 19 in vivo studies, 1 published clinical trial, 4 in vitro studies and 2 studies comprising both in vivo and in vitro methods. and its bioactive phytoconstituent, 3-n-butylphthalide (NBP), have demonstrated their effect on neurological disorders such as Alzheimer's disease, Parkinson's disease, stroke-related neurological complications, depression, diabetes-related neurological complications, and epilepsy. The safety findings were minimal, showing that NBP is safe for up to 18 weeks at 15 mg/kg in animal studies, while there were adverse effects (7%) reported when consuming NBP for 24 weeks at 600 mg daily in human trials. In conclusion, the safety of extract and NBP can be further investigated clinically on different neurological disorders based on their potential role in different targeted pathways.
芹菜是伞形科或伞形科的一种土生植物，含有许多活性化合物。它传统上被用于治疗关节炎、痛风和尿路感染。作者进行了范围综述，以评估芹菜治疗神经紊乱时的整体效果的现有证据的质量。使用选定的电子数据库中的预定关键字进行了系统搜索。筛选后包含的 26 篇文章包括 19 项体内研究、1 项已发表的临床试验、4 项体外研究和 2 项包含体内和体外方法的研究。芹菜及其生物活性植物成分 3-正丁基苯酞 (NBP) 已证明对神经紊乱有影响，如阿尔茨海默病、帕金森病、中风相关神经并发症、抑郁症、糖尿病相关神经并发症和癫痫。安全性发现很少，表明在动物研究中，NBP 每天 15 毫克/公斤时最多可安全使用 18 周，而在人体试验中每天 600 毫克时连续使用 24 周时则有不良反应（7%）。总之，根据芹菜提取物和 NBP 在不同靶向途径中的潜在作用，可以进一步在不同的神经紊乱方面进行临床安全性研究。
