一种新兴病原体，也是儿童伤口感染的罕见病因。
: An emerging pathogen and rare cause of wound infection in children.
作者信息
Krueger Carsten, Ann Azad Marisa, Ramotar Karamchand, Deslandes Vincent, Jessamine Peter
机构信息
Division of Infectious Diseases, Immunology & Allergy, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada.
The Ottawa Hospital Research Institute (OHRI), Ottawa, Ontario, Canada.
出版信息
J Assoc Med Microbiol Infect Dis Can. 2022 Sep 27;7(3):279-282. doi: 10.3138/jammi-2021-0038. eCollection 2022 Sep.
BACKGROUND
is an anaerobic gram-positive bacilli first isolated from swine manure in 2003 but has since been associated with human infections.
METHODS
We describe a pediatric case of infection following a below-knee amputation for a limb injury and its treatment. Methods of identifying and reported in vitro antimicrobial minimum inhibitory concentrations from the literature are reviewed.
RESULTS
is readily identifiable via 16S rRNA gene sequencing and Matrix-Assisted Laser Desorption Ionization-Time of Flight. There is variability in the antibiotic susceptibility profiles reported in the literature, but antibiotics with low minimum inhibitor concentrations against include beta-lactam/beta-lactamase inhibitors, carbapenems, vancomycin, and metronidazole.
CONCLUSION
This is the first reported case of infection following a traumatic injury in Canada to our knowledge and highlights the importance of recognizing this organism and other anaerobes in settings where wounds are grossly contaminated with soil.
背景
[细菌名称]是一种厌氧革兰氏阳性杆菌，2003年首次从猪粪中分离出来，但此后一直与人类感染有关。
方法
我们描述了一例因肢体损伤行膝下截肢术后发生[细菌名称]感染的儿科病例及其治疗情况。回顾了从文献中鉴定[细菌名称]以及报告体外抗菌药物最低抑菌浓度的方法。
结果
通过16S rRNA基因测序和基质辅助激光解吸电离飞行时间质谱很容易鉴定出[细菌名称]。文献报道的抗生素敏感性谱存在差异，但对[细菌名称]最低抑菌浓度较低的抗生素包括β-内酰胺/β-内酰胺酶抑制剂、碳青霉烯类、万古霉素和甲硝唑。
结论
据我们所知，这是加拿大首例报道的创伤后[细菌名称]感染病例，强调了在伤口被土壤严重污染的情况下识别这种细菌和其他厌氧菌的重要性。
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