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COVID-19 患者粪便标本中缺乏 SARS-CoV-2 的生存能力和感染力的证据。

Lack of evidence of viability and infectivity of SARS-CoV-2 in the fecal specimens of COVID-19 patients.

机构信息

Enteric Viruses Group, ICMR-National Institute of Virology, Pune, India.

Microbial Containment Laboratory, ICMR-National Institute of Virology, Pune, India.

出版信息

Front Public Health. 2022 Oct 20;10:1030249. doi: 10.3389/fpubh.2022.1030249. eCollection 2022.

DOI:10.3389/fpubh.2022.1030249
PMID:36339137
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9632423/
Abstract

SARS-CoV-2 can be shed in feces and can enter sewage systems. In order to implement effective control measures and identify new channels of transmission, it is essential to identify the presence of infectious virus particles in feces and sewage. In this study, we attempt to utilize Molecular techniques, cell cultures and animal models to find out the infectivity of SARS-CoV-2 in the feces of COVID-19 patients. Our findings exclude the presence of infectious virus particles, suggesting that fecal-oral transmission may not be the main mode of transmission. Larger-scale initiatives are nevertheless required, particularly considering the emergence of new viral strains.

摘要

SARS-CoV-2 可以在粪便中排出，并可能进入污水系统。为了实施有效的控制措施和发现新的传播途径，确定粪便和污水中是否存在传染性病毒颗粒至关重要。在这项研究中，我们尝试利用分子技术、细胞培养和动物模型来确定 COVID-19 患者粪便中的 SARS-CoV-2 的感染性。我们的研究结果排除了传染性病毒颗粒的存在，表明粪-口传播可能不是主要的传播方式。然而，仍需要更大规模的举措，特别是考虑到新病毒株的出现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/9632423/a75f0260752e/fpubh-10-1030249-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/9632423/a75f0260752e/fpubh-10-1030249-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/572b/9632423/a75f0260752e/fpubh-10-1030249-g0001.jpg

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