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肺移植患者的嗜肺军团菌感染以及基质辅助激光解吸电离飞行时间质谱在准确细菌鉴定中的关键作用。

sp infection in a lung transplant patient and the critical role of MALDI-TOF in accurate bacterial identification.

作者信息

Boutin Catherine-Audrey, Cornut Gilbert, Bilik Pinto Véronica, Grandjean Lapierre Simon

机构信息

Université de Montréal, Montréal, Quebec, Canada.

Fleury Hospital, Montréal, Quebec, Canada.

出版信息

J Assoc Med Microbiol Infect Dis Can. 2020 Oct 11;5(3):177-181. doi: 10.3138/jammi-2020-0001. eCollection 2020 Oct.

Abstract

Diagnosis and clinical management of pulmonary infections in lung transplant patients are challenging. The increased diversity of bacterial species identified from clinical samples with novel proteomics-based systems can further complicate clinical decision making in this highly vulnerable population. Whether newly recognized organisms are colonizers or true pathogens often remains controversial since symptoms causality and impact on lung function is often unknown. We present the case of a 48-year-old female lung transplant patient with sp infection. We review and discuss the role of matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for accurate bacterial identification. We report on therapeutic management and clinical outcome.

摘要

肺移植患者肺部感染的诊断和临床管理具有挑战性。基于新型蛋白质组学系统从临床样本中鉴定出的细菌种类日益多样化,这可能会使这个高度脆弱人群的临床决策更加复杂。新发现的生物体是定植菌还是真正的病原体往往仍存在争议,因为症状的因果关系以及对肺功能的影响通常并不明确。我们报告一例48岁女性肺移植患者发生sp感染的病例。我们回顾并讨论基质辅助激光解吸/电离飞行时间质谱(MALDI-TOF MS)在准确细菌鉴定中的作用。我们报告治疗管理情况和临床结果。

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