二维层状双氢氧化物纳米粒子的生物聚合物表面修饰及其在生物医学中的应用。
Surface modification of two-dimensional layered double hydroxide nanoparticles with biopolymers for biomedical applications.
机构信息
Department of Physics and John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA; BioSense Institute, University of Novi Sad, Dr Zorana Djindjica 1, Novi Sad 21000, Serbia.
MTA-SZTE Lendület Biocolloids Research Group, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary; Department of Physical Chemistry and Materials Science, University of Szeged, Rerrich Béla tér 1, Szeged 6720, Hungary.
出版信息
Adv Drug Deliv Rev. 2022 Dec;191:114590. doi: 10.1016/j.addr.2022.114590. Epub 2022 Oct 29.
Layered double hydroxides (LDHs) are appealing nanomaterials for (bio)medical applications and their potential is threefold. One can gain advantage of the structure of LDH frame (i.e., layered morphology), anion exchanging property towards drugs with acidic character and tendency for facile surface modification with biopolymers. This review focuses on the third aspect, as it is necessary to evaluate the advantages of polymer adsorption on LDH surfaces. Beside the short discussion on fundamental and structural features of LDHs, LDH-biopolymer interactions will be classified in terms of the effect on the colloidal stability of the dispersions. Thereafter, an overview on the biocompatibility and biomedical applications of LDH-biopolymer composite materials will be given. Finally, the advances made in the field will be summarized and future research directions will be suggested.
层状双氢氧化物（LDHs）是一种具有吸引力的医学应用纳米材料，其潜力有三个方面。人们可以利用 LDH 层的结构（即层状形态）、对具有酸性特征的药物的阴离子交换特性以及易于与生物聚合物进行表面修饰的特性。本文重点介绍第三个方面，因为有必要评估聚合物在 LDH 表面吸附的优势。除了对 LDH 基本结构特征的简短讨论外，还将根据分散体胶体稳定性的影响对 LDH-生物聚合物相互作用进行分类。然后，将对 LDH-生物聚合物复合材料的生物相容性和医学应用进行综述。最后，总结该领域的进展，并提出未来的研究方向。
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