School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China.
School of Food and Biological Engineering, Hefei University of Technology, Hefei, 230009, People's Republic of China; School of Biological Science and Engineering, Collaborative Innovation Center for Food Production and Safety, North Minzu University, Yinchuan, 750021, People's Republic of China.
Food Chem Toxicol. 2022 Dec;170:113499. doi: 10.1016/j.fct.2022.113499. Epub 2022 Oct 29.
Endometrial cancer remains as one of the widespread female malignancies despite the existing treatment measures mainly surgery, radiotherapy, and chemotherapy. In recent times, studies have focused on medicinal plants such as ginger due to its multifaceted characteristics compared to conventional medicine. 6-Shogaol is regarded as the main active compound of ginger participating in pharmacological activities and combating various health disorders, especially cancer. In our study, we compared the effects of 6-gingerol, 6-paradol, and 6-shogaol on Ishikawa cells, and found 6-shogaol as a more effective ingredient against Ishikawa cell proliferation. Moreover, its promoted ferroptosis, as a result, triggered mitochondrial morphologic alternation, as well as changed iron concentration, GSH and MDA levels. Furthermore, 6-Shogaol inhibited cell metastasis by influencing cell invasion and migration. Finally, 6-shogaol could trigger PI3K/AKT signaling pathways in vitro and in vivo confirmed by western blotting assay and immunohistochemical evaluation. These findings suggest that 6-shogaol can be used as promising functional food component in health diet and in drug target methods for endometrial cancer therapy.
子宫内膜癌仍然是女性常见的恶性肿瘤之一，尽管现有的治疗方法主要是手术、放疗和化疗。近年来，研究集中在药用植物上，如生姜，因为它与传统药物相比具有多方面的特性。6-姜酚被认为是生姜参与药理活性和对抗各种健康障碍的主要活性化合物，特别是癌症。在我们的研究中，我们比较了 6-姜酚、6-姜酮和 6-姜辣素对 Ishikawa 细胞的影响，发现 6-姜辣素是一种更有效的抑制 Ishikawa 细胞增殖的成分。此外，它促进了铁死亡，从而引发了线粒体形态的改变，以及铁浓度、GSH 和 MDA 水平的变化。此外，6-姜辣素通过影响细胞侵袭和迁移来抑制细胞转移。最后，通过 Western blot 分析和免疫组织化学评价，证实 6-姜辣素可以在体外和体内触发 PI3K/AKT 信号通路。这些发现表明，6-姜辣素可以作为一种有前途的功能性食品成分，用于健康饮食和子宫内膜癌治疗的药物靶点方法。
