Department of Paediatrics, College of Medicine, University of Nigeria Enugu Campus, Nsukka, Nigeria.
Department of Paediatrics, University of Nigeria Teaching Hospital, Ituku- Ozalla, Enugu, Nigeria.
BMC Pediatr. 2022 Nov 9;22(1):652. doi: 10.1186/s12887-022-03719-y.
To determine the prevalence and factors associated with left ventricular diastolic dysfunction in children with HIV/AIDS.
Echocardiographic studies were carried out in 90 children/adolescents aged 18 months to 14 years. with HIV/AIDS and a healthy control group of 90 age and gender matched.
47.8% of the HIV/AIDS patients (subjects) had LVDD. This was more pronounced in the AIDS group (100%). The E/A ratio was 1.9 ± 0.56 in the HIV group, 2.09 ± 0.04 in the AIDS group, and 1.20 ± 0.39 in the control group (p = 0.04). The mean Left ventricular isovolumic relaxation time (IVRT) was 79.4 ± 20.12 in the HIV group, 110.4 ± 10.12 in the AIDS group and 89.22 ± 25.76 in the control group. (p = 0.04). Deceleration time (DT) was also lower in HIV carrier group compared to AIDS group, p = 0.02. A restrictive filling pattern was the most described; with 27 (36.5%) in the HIV group, 16 (100.0%) in the AIDS group and 2 (2.2%) in the control group. (p = 0.02). The impaired relaxation pattern, 3 (4.0%) seen in the HIV group only. Positive correlation exists between body surface area (BSA) and LVDD. Body surface area and younger age were the significant predictors (BSA: r = 0.425, p = 0.038 in HIV and r = 0.827, p = 0.042) of LVDD in the AIDS group.
This study showed a high prevalence of LVDD in Nigerian children with HIV and AIDS. This justifies inclusion of echocardiographic studies in the policy care of children with HIV/AIDS in sub-Sahara Africa region.
确定 HIV/AIDS 患儿左心室舒张功能障碍的患病率及其相关因素。
对 90 名 18 个月至 14 岁的 HIV/AIDS 患儿和 90 名年龄和性别匹配的健康对照组进行超声心动图研究。
47.8%的 HIV/AIDS 患儿（研究对象）存在 LVDD。艾滋病组更为明显（100%）。HIV 组的 E/A 比值为 1.9±0.56，艾滋病组为 2.09±0.04，对照组为 1.20±0.39（p=0.04）。HIV 组的左心室等容舒张时间（IVRT）平均值为 79.4±20.12，艾滋病组为 110.4±10.12，对照组为 89.22±25.76（p=0.04）。减速时间（DT）在 HIV 携带者组也低于艾滋病组，p=0.02。限制型充盈模式为最常见的描述模式；HIV 组有 27 例（36.5%），艾滋病组有 16 例（100.0%），对照组有 2 例（2.2%）（p=0.02）。仅在 HIV 组观察到舒张功能障碍模式，有 3 例（4.0%）。BSA 与 LVDD 之间存在正相关。BSA 和年龄较小是艾滋病组 LVDD 的显著预测因素（BSA：在 HIV 中 r=0.425，p=0.038；在艾滋病中 r=0.827，p=0.042）。
本研究显示，尼日利亚 HIV 和艾滋病患儿 LVDD 的患病率较高。这证明在撒哈拉以南非洲地区，将超声心动图研究纳入 HIV/AIDS 患儿的政策护理是合理的。
