Institut für Medizinische Mikrobiologie und Krankenhaushygiene, Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany.
Universitätsklinik für Plastische, Ästhetische und Handchirurgie Medizinische Fakultät der Otto-von-Guericke Universität Magdeburg, Magdeburg, Germany.
Front Cell Infect Microbiol. 2022 Oct 24;12:981477. doi: 10.3389/fcimb.2022.981477. eCollection 2022.
is a facultative anaerobic, environmentally stable, Gram-positive rod that causes swine and avian erysipelas as a zoonotic pathogen. In humans, the main manifestations described are circumscribed erysipeloid, generalized erysipeloid, and endocarditis. Here, we report a 46-year-old female patient who presented to the physician because of redness and marked of the hand, in terms of a pain-related restricted range of motion, and was treated surgically. was detected in tissue biopsy. The source of infection was considered to be a pond in which both swine and, later, her dog bathed. The genome of the isolate was completely sequenced and especially the presumptive virulence associated factors as well as the presumptive antimicrobial resistance genes, in particular a predicted homologue to the multiple sugar metabolism regulator (MsmR), several predicted two-component signal transduction systems, three predicted hemolysins, two predicted neuraminidases, three predicted hyaluronate lyases, the surface protective antigen SpaA, a subset of predicted enzymes that potentially confer resistance to reactive oxygen species (ROS), several predicted phospholipases that could play a role in the escape from phagolysosomes into host cell cytoplasm as well as a predicted vancomycin resistance locus () and three predicted MATE efflux transporters were investigated in more detail.
猪丹毒丝菌是一种兼性厌氧、环境稳定的革兰氏阳性杆菌,作为一种人畜共患病病原体引起猪和禽丹毒。在人类中,描述的主要表现为局限性丹毒样红斑、全身性丹毒样红斑和心内膜炎。在这里,我们报告了一例 46 岁女性患者,因手部红肿和明显疼痛导致活动受限而就诊,并接受了手术治疗。在组织活检中发现了 。感染源被认为是一个池塘,猪和后来她的狗都在那里洗澡。对分离株的基因组进行了全序列测序,特别是与假定毒力相关的因素以及假定的抗微生物药物耐药基因,特别是一个预测的多糖代谢调节剂(MsmR)同源物、几个预测的双组分信号转导系统、三个预测的溶血素、两个预测的神经氨酸酶、三个预测的透明质酸酶、表面保护性抗原 SpaA、一组潜在的赋予抵抗活性氧 (ROS) 的酶、几个预测的可能在逃避吞噬体进入宿主细胞质中起作用的磷脂酶以及一个预测的万古霉素耐药基因 (vanA) 和三个预测的 MATE 外排转运蛋白进行了更详细的研究。