Modica Roberta, La Salvia Anna, Liccardi Alessia, Cannavale Giuseppe, Minotta Roberto, Benevento Elio, Faggiano Antongiulio, Colao Annamaria
Department of Clinical Medicine and Surgery, Endocrinology Unit of Federico II University of Naples, 80131 Naples, Italy.
Division of Medical Oncology 2, IRCCS Regina Elena National Cancer Institute, 00144 Rome, Italy.
Metabolites. 2022 Nov 2;12(11):1057. doi: 10.3390/metabo12111057.
Lipid metabolism is known to be involved in tumorigenesis and disease progression in many common cancer types, including colon, lung, breast and prostate, through modifications of lipid synthesis, storage and catabolism. Furthermore, lipid alterations may arise as a consequence of cancer treatment and may have a role in treatment resistance. Neuroendocrine neoplasms (NENs) are a heterogeneous group of malignancies with increasing incidence, whose mechanisms of cancer initiation and progression are far from being fully understood. Alterations of lipid metabolism may be common across various cancer types, but data about NENs are scattered and heterogeneous. Herein, we provide an overview of the relevant literature on lipid metabolism and alterations in NENs. The available evidence both in basic and clinical research about lipid metabolism in NENs, including therapeutic effects on lipid homeostasis, are summarized. Additionally, the potential of targeting the lipid profile in NEN therapy is also discussed, and areas for further research are proposed.
已知脂质代谢通过脂质合成、储存和分解代谢的改变，参与包括结肠癌、肺癌、乳腺癌和前列腺癌在内的多种常见癌症类型的肿瘤发生和疾病进展。此外，脂质改变可能是癌症治疗的结果，并且可能在治疗耐药中起作用。神经内分泌肿瘤（NENs）是一组异质性恶性肿瘤，发病率不断上升，其癌症发生和进展机制远未完全明了。脂质代谢改变可能在各种癌症类型中普遍存在，但关于NENs的数据零散且不统一。在此，我们概述了关于NENs脂质代谢及其改变的相关文献。总结了基础和临床研究中有关NENs脂质代谢的现有证据，包括对脂质稳态的治疗作用。此外，还讨论了在NEN治疗中靶向脂质谱的潜力，并提出了进一步研究的领域。
