Srichomphu Pratthana, Wattanathorn Jintanaporn, Thukham-Mee Wipawee, Muchimapura Supaporn
Department of Physiology and Graduate School (Neuroscience Program), Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Research Institute for High Human Performance and Health Promotion, Khon Kaen University, Khon Kaen 40002, Thailand.
Antioxidants (Basel). 2022 Nov 7;11(11):2203. doi: 10.3390/antiox11112203.
Despite an increase in the coexistence of metabolic syndrome (MetS) and psychological disorders, together with their great impact on socio-economic burdens, no protective strategies that focus on these situations are available. Due to the role of oxidative stress in the pathophysiology of metabolic syndrome (MetS) and psychological disorders, we hypothesized that substances possessing antioxidant activity such as the novel functional ingredients from (AO) could mitigate common psychological disorders in MetS rats. Male Wistar rats, weighing 200-250 g, were induced with MetS through a 12-week high-fat and high-cholesterol diet (HFHC). Then, they were given AO orally via a gastric gavage needle at doses of 1, 10 and 100 mg/kg BW for 14 days. Spatial memory, anxiety, depression, and sleep behaviors, together with changes in oxidative stress status and neurotransmitters, were assessed. All doses of AO significantly improved memory, anxiety, and sleep, together with the suppression of oxidative stress, AChE, and GABA-T in the cerebral cortex and hippocampus. These results suggest the protective effect of AO against anxiety, insomnia, and memory impairment that coexist with the MetS condition via an improvement in oxidative stress and the functions of the cholinergic and GABAergic systems. However, this benefit requires clinical confirmation.
尽管代谢综合征（MetS）与心理障碍并存的情况有所增加，且它们对社会经济负担有重大影响，但目前尚无针对这些情况的保护性策略。由于氧化应激在代谢综合征（MetS）和心理障碍的病理生理学中起作用，我们推测具有抗氧化活性的物质，如来自[具体来源未提及]的新型功能成分（AO），可以减轻MetS大鼠常见的心理障碍。体重200 - 250克的雄性Wistar大鼠通过12周的高脂高胆固醇饮食（HFHC）诱导形成MetS。然后，通过胃管针以1、10和100毫克/千克体重的剂量给它们口服AO，持续14天。评估空间记忆、焦虑、抑郁和睡眠行为，以及氧化应激状态和神经递质的变化。所有剂量的AO均显著改善了记忆、焦虑和睡眠，同时抑制了大脑皮层和海马体中的氧化应激、乙酰胆碱酯酶（AChE）和γ-氨基丁酸转氨酶（GABA-T）。这些结果表明，AO通过改善氧化应激以及胆碱能和γ-氨基丁酸能系统的功能，对与MetS状况共存的焦虑、失眠和记忆障碍具有保护作用。然而，这种益处需要临床证实。
