Pirali-Hamedani Zeynab, Abbasi Ardeshir, Hassan Zuhair Mohammad
Department of Immunology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran 1411713116, Iran.
Biomedicines. 2022 Oct 26;10(11):2713. doi: 10.3390/biomedicines10112713.
Colorectal cancer is the third most common cancer in the world. Due to the side effects of common treatments such as chemotherapy and radiotherapy, the use of herbal medicines has received much attention. Artemether (ARM) is an herbal medicine derived from artemisinin, which has many anti-tumor properties. However, factors such as low solubility and short half-life have limited the use of artemether in clinical practice. In this study, we aimed to reduce these limitations by encapsulating artemether in human serum albumin (HSA). The hydrodynamic diameter and the zeta potential value of ARM-ALB nanoparticles (NPs) were 171.3 ± 5.88 nm and -19.1 ± 0.82 mV, respectively. Comparison of the effect of free and encapsulated artemether on CT 26 cell line showed that the use of artemether in capsulated form can reduce the effective concentration of the drug. Additionally, in vivo studies have also shown that albumin-artemether nanoparticles can control tumor growth by increasing the production of cytokine IFN-γ and decreasing the production of IL4. Therefore, ARM-ALB nanoparticles have greater anti-tumor effects than free artemether.
结直肠癌是全球第三大常见癌症。由于化疗和放疗等常规治疗的副作用，草药的使用受到了广泛关注。蒿甲醚（ARM）是一种源自青蒿素的草药，具有多种抗肿瘤特性。然而，低溶解度和短半衰期等因素限制了蒿甲醚在临床实践中的应用。在本研究中，我们旨在通过将蒿甲醚封装在人血清白蛋白（HSA）中来减少这些限制。ARM-ALB纳米颗粒（NPs）的流体动力学直径和zeta电位值分别为171.3±5.88nm和-19.1±0.82mV。游离蒿甲醚和封装蒿甲醚对CT 26细胞系作用的比较表明，使用封装形式的蒿甲醚可以降低药物的有效浓度。此外，体内研究还表明，白蛋白-蒿甲醚纳米颗粒可以通过增加细胞因子IFN-γ的产生和减少IL4的产生来控制肿瘤生长。因此，ARM-ALB纳米颗粒比游离蒿甲醚具有更强的抗肿瘤作用。
