Rangarajan Subhapradha, Orujyan Davit, Rangchaikul Patrida, Radwan Mohamed M
College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Biomedicines. 2022 Nov 6;10(11):2829. doi: 10.3390/biomedicines10112829.
Recent research on how the body resolves this inflammation is gaining traction and has shed light on new avenues for future management of cardiovascular diseases. In this narrative review, we discuss the pathophysiological mechanisms of atherosclerosis, the recent development in the understanding of a new class of molecules called Specialized Pro-resolving Mediators (SPMs), and the impact of such findings in the realm of cardiovascular treatment options. We searched the MEDLINE database restricting ourselves to original research articles as much as possible on the complex pathophysiology of atherosclerosis and the role of SPMs. We expect to see further research in translating these findings to bedside clinical trials in treating conditions with a pathophysiological basis of inflammation, such as coronary artery disease, asthma, and periodontal disease.
近期关于身体如何解决这种炎症的研究正越来越受到关注，并为心血管疾病的未来管理开辟了新途径。在这篇叙述性综述中，我们讨论了动脉粥样硬化的病理生理机制、对一类名为特殊促消退介质（SPMs）的新分子的认识进展，以及这些发现对心血管治疗选择领域的影响。我们检索了MEDLINE数据库，尽可能将搜索范围限制在关于动脉粥样硬化复杂病理生理学和SPMs作用的原创研究文章。我们期待看到进一步的研究，将这些发现转化为针对具有炎症病理生理基础的疾病（如冠状动脉疾病、哮喘和牙周病）的床边临床试验。
