Department of Nephrology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Cells. 2022 Oct 31;11(21):3443. doi: 10.3390/cells11213443.
Cellular senescence is described as the state where the cell cycle is arrested irreversibly, which occurs in response to various forms of stress factors in cells, leading to the senescence-associated secretory phenotype (SASP). We can assess the accumulation of senescent cells in tissues or organs through biomarkers of cellular senescence such as p16, p53, p21, and SA-β-GAL. In recent decades, a large number of studies have reported the biomarkers of increased cell senescence in pathogenic tissues, demonstrating the possible connection between cell senescence and various diseases. Kidney damage often occurs in the pathophysiological process of certain metabolic diseases, resulting in metabolic-associated kidney diseases. For example, hypertension causes systemic arteriosclerosis, and the kidney can be seriously affected by abundant blood vessels, which may lead to a decreased glomerular filtration rate (GFR) and proteinuria, resulting in hypertension-related kidney diseases. The accumulation of senescent cells may also be observed in some metabolic-associated kidney diseases (such as obesity-related nephropathy, hypertension-related nephropathy, and diabetic nephropathy). In this paper, we review existing knowledge regarding the influence of cellular senescence on metabolic-associated kidney diseases, providing new ideas for future treatment.
细胞衰老被描述为细胞周期不可逆停滞的状态，这是细胞对各种形式的应激因素的反应，导致衰老相关分泌表型（SASP）。我们可以通过细胞衰老的生物标志物，如 p16、p53、p21 和 SA-β-GAL，来评估组织或器官中衰老细胞的积累。近几十年来，大量研究报告了在致病组织中细胞衰老增加的生物标志物，表明细胞衰老与各种疾病之间可能存在联系。肾脏损伤通常发生在某些代谢疾病的病理生理过程中，导致代谢相关的肾脏疾病。例如，高血压引起全身动脉硬化，肾脏可因富含血管而受到严重影响，可能导致肾小球滤过率（GFR）下降和蛋白尿，从而导致与高血压相关的肾脏疾病。在一些代谢相关的肾脏疾病（如肥胖相关的肾病、高血压相关的肾病和糖尿病肾病）中也可能观察到衰老细胞的积累。本文综述了细胞衰老对代谢相关肾脏疾病的影响，为未来的治疗提供了新的思路。
