Clinical Dietetics Unit, Department of Bioanalytics, Medical University of Lublin, ul. Chodzki 7, 20-093 Lublin, Poland.
Department of Cardiology, Cardinal Wyszynski Hospital in Lublin, al. Krasnicka 100, 20-718 Lublin, Poland.
Nutrients. 2022 Nov 1;14(21):4586. doi: 10.3390/nu14214586.
Background: Recent studies suggest the positive role of flavonols on blood pressure (BP) values, although there are not many conducted on humans. The aim of this study was to examine the relationship between flavonol intake and their main sources of consumption, and systolic (SBP) and diastolic (DBP) BP values in coronary artery disease (CAD) patients. Methods and results: forty CAD patients completed a food-frequency questionnaire dedicated to flavonol-intake assessment. The analysis revealed significant correlation between isorhamnetin intake and SBP values—absolute (R: −0.36; 95% CI: −0.602 to −0.052; p = 0.02), and related to body mass (R: −0.38; 95% CI: −0.617 to −0.076; p = 0.02. This effect was observed in male participants (R: −0.65; 95% CI: −0.844 to −0.302; p = 0.001 and R: −0.63; 95% CI: −0.837 to −0.280; p = 0.002 respectively), but not in female patients. The main contributors were onions, tomatoes, blueberries, apples, tea, coffee and wine. White onion (R: −0.39; 95% CI: −0.624 to −0.088; p = 0.01) consumption was inversely correlated with SBP, and tomato consumption (R: −0.33; 95% CI: −0.581 to −0.020; p = 0.04) with DBP. The comparison between patients with BP < 140 mmHg and ≥140 mmHg revealed significant differences in white onion (p = 0.01) and blueberry (p = 0.04) intake. Conclusions: This study revealed the relationship between long-term dietary isorhamnetin intake and SBP values. The analysis of specific food intake showed that onion, tomato and blueberry consumption could impact BP values. This may suggest that a dietary approach which includes a higher intake of isorhamnetin-rich products could possibly result in BP lowering in CAD patients.
最近的研究表明，类黄酮对血压（BP）值有积极作用，尽管针对人类的研究并不多。本研究旨在探讨类黄酮摄入量与其主要消费来源以及冠心病（CAD）患者收缩压（SBP）和舒张压（DBP）值之间的关系。
40 名 CAD 患者完成了专门评估类黄酮摄入量的食物频率问卷。分析显示，异鼠李素摄入量与 SBP 值呈显著相关——绝对值（R：-0.36；95%置信区间：-0.602 至 -0.052；p = 0.02），且与体重相关（R：-0.38；95%置信区间：-0.617 至 -0.076；p = 0.02）。这种影响仅在男性参与者中观察到（R：-0.65；95%置信区间：-0.844 至 -0.302；p = 0.001 和 R：-0.63；95%置信区间：-0.837 至 -0.280；p = 0.002），而在女性患者中则没有。主要来源是洋葱、西红柿、蓝莓、苹果、茶、咖啡和酒。白洋葱（R：-0.39；95%置信区间：-0.624 至 -0.088；p = 0.01）的摄入与 SBP 呈负相关，而番茄的摄入（R：-0.33；95%置信区间：-0.581 至 -0.020；p = 0.04）与 DBP 呈负相关。血压 <140mmHg 和≥140mmHg 的患者之间的比较显示，白洋葱（p = 0.01）和蓝莓（p = 0.04）的摄入量存在显著差异。
本研究揭示了长期饮食中异鼠李素摄入与 SBP 值之间的关系。特定食物摄入的分析表明，洋葱、番茄和蓝莓的摄入可能会影响血压值。这表明，包括摄入更多富含异鼠李素的产品在内的饮食方法可能会导致 CAD 患者的血压降低。
