Noroozi M, Burns J, Crozier A, Kelly I E, Lean M E
Department of Human Nutrition, University of Glasgow, Glasgow Royal Infirmary, Glasgow, Scotland, UK.
Eur J Clin Nutr. 2000 Feb;54(2):143-9. doi: 10.1038/sj.ejcn.1600908.
to predict flavonols content of the habitual diets of free-living subjects from urine and plasma concentrations of flavonols.
Ten type 2 diabetic patients (five male, five female), mean age 60 (s.e.m. 7) y and BMI 30.2 (s.e.m. 3.5) kg/m2 were treated in a random crossover design for a 2 week period on either a low flavonoid diet or on the same diet supplemented at one of two high flavonols levels (total 77.3 or 110.4 mg/day) provided by supplements of 1500 ml tea daily and 400 g fried white onion in olive oil with and without tomato ketchup and herbs.
Glasgow Royal Infirmary, University of Glasgow, Scotland.
Fasting plasma concentration, urine concentration and 24 h excretion of quercetin, isorhamnetin, kaempferol and myricetin.
Plasma flavonol concentration (r=0.750, P=0.001), 24 h urine concentration (r=0.847, P=0.001) and 24 h urine excretion (r=0.728, P=<0.001) were all highly significantly related to dietary intake and gave similar estimates of intakes. Fasting plasma flavonols concentrations on habitual diets ranged from 0 to 43.7 ng/ml mean. Regression equations were constricted: total flavonols intake r=0.74, P<0.001 and quercetin intake r=0.744, P<0. 001. From these equations, flavonol intakes from habitual diets were estimated at 17-50, mean 35 mg/day. Of this, 91% was from quercetin.
Dietary flavonols are absorbed and appear in plasma and urine as potential biomarkers in concentrations related quantitatively to intake. Estimation of dietary intake from plasma or urine concentrations appears possible.
Rank Prize Funds and Rank Foundation of the Department of Human Nutrition; Ministry of Health and Medical Education, IR Iran. European Journal of Clinical Nutrition (2000) 54, 143-149
根据尿样和血浆中黄酮醇的浓度，预测自由生活人群日常饮食中黄酮醇的含量。
10名2型糖尿病患者（5名男性，5名女性），平均年龄60（标准误7）岁，体重指数30.2（标准误3.5）kg/m²，采用随机交叉设计，在为期2周的时间里，分别采用低黄酮类饮食，或在同样的饮食基础上补充两种高黄酮醇水平（分别为每日77.3或110.4毫克）之一，通过每日补充1500毫升茶以及400克用橄榄油煎制的白洋葱，并添加或不添加番茄酱和香草来实现。
苏格兰格拉斯哥大学格拉斯哥皇家医院。
槲皮素、异鼠李素、山奈酚和杨梅素的空腹血浆浓度、尿液浓度及24小时排泄量。
血浆黄酮醇浓度（r = 0.750，P = 0.001）、24小时尿液浓度（r = 0.847，P = 0.001）和24小时尿液排泄量（r = 0.728，P < 0.001）均与饮食摄入量高度显著相关，且对摄入量的估计相似。日常饮食中空腹血浆黄酮醇浓度范围为0至43.7纳克/毫升（均值）。构建了回归方程：总黄酮醇摄入量r = 0.74，P < 0.001；槲皮素摄入量r = 0.744，P < 0.001。根据这些方程，日常饮食中黄酮醇摄入量估计为17 - 50毫克/天，均值为35毫克/天。其中，91%来自槲皮素。
膳食黄酮醇可被吸收，并以与摄入量定量相关的浓度出现在血浆和尿液中，作为潜在的生物标志物。通过血浆或尿液浓度估计膳食摄入量似乎是可行的。
兰克奖基金和人类营养系兰克基金会；伊朗伊斯兰共和国卫生和医学教育部。《欧洲临床营养学杂志》（2000年）54卷，143 - 149页
